(+/-)-phenyl-phenylcarbamoyl-methanesulfonic acid ; (+/-)-α-sulfo-phenylacetic acid anilide

Base Information

• Chemical Name: (+/-)-phenyl-phenylcarbamoyl-methanesulfonic acid ; (+/-)-α-sulfo-phenylacetic acid anilide
• CAS No.: 858004-74-7
• Molecular Formula: C₁₄H₁₃NO₄S
• Molecular Weight: 291.328
• Mol file: 858004-74-7.mol

Synonyms:

Chemical Property of (+/-)-phenyl-phenylcarbamoyl-methanesulfonic acid ; (+/-)-α-sulfo-phenylacetic acid anilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-phenyl-phenylcarbamoyl-methanesulfonic acid ; (+/-)-α-sulfo-phenylacetic acid anilide

There total 3 articles about (+/-)-phenyl-phenylcarbamoyl-methanesulfonic acid ; (+/-)-α-sulfo-phenylacetic acid anilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-sulpho-2-phenylacetyl chloride (40125-73-3) + aniline (62-53-3) → (+/-)-phenyl-phenylcarbamoyl-methanesulfonic acid ; (+/-)-α-sulfo-phenylacetic acid anilide (858004-74-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/acsmedchemlett.5b00373

Reference yield:

racemic α-sulfophenylacetic acid (41360-32-1) + aniline (62-53-3) → (+/-)-phenyl-phenylcarbamoyl-methanesulfonic acid ; (+/-)-α-sulfo-phenylacetic acid anilide (858004-74-7)

Guidance literature:

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/acs.jmedchem.6b00993

Reference yield:

aniline (62-53-3) + (-)-phenyl-phenylcarbamoyl-methanesulfonic acid → (+/-)-phenyl-phenylcarbamoyl-methanesulfonic acid ; (+/-)-α-sulfo-phenylacetic acid anilide (858004-74-7)

Guidance literature:

upstream raw materials:

aniline

2-sulpho-2-phenylacetyl chloride

racemic α-sulfophenylacetic acid

Downstream raw materials:

aniline