(3R)-3-{1-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]ethyl}heptyl-4-methyl benzenesulfonate

Base Information

Chemical Name:(3R)-3-{1-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]ethyl}heptyl-4-methyl benzenesulfonate
CAS No.:1608457-67-5
Molecular Formula:C₄₇H₈₀O₅SSi₂
Molecular Weight:813.386
Hs Code.:

(3R)-3-{1-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]ethyl}heptyl-4-methyl benzenesulfonate

Synonyms:

Suppliers and Price of (3R)-3-{1-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]ethyl}heptyl-4-methyl benzenesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R)-3-{1-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]ethyl}heptyl-4-methyl benzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R)-3-{1-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]ethyl}heptyl-4-methyl benzenesulfonate

There total 3 articles about (3R)-3-{1-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]ethyl}heptyl-4-methyl benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1608457-61-9
(3R)-3-{1-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]ethyl}heptan-1-ol

: 98-59-9
p-toluenesulfonyl chloride

: 1608457-67-5
(3R)-3-{1-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]ethyl}heptyl-4-methyl benzenesulfonate

Guidance literature:: With pyridine; at 0 ℃; for 15h;
DOI:10.1021/jm500392t

Reference yield:

: 1237750-59-2
ethyl (2E)-4-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]pent-2-enoate

: 1608457-67-5
(3R)-3-{1-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]ethyl}heptyl-4-methyl benzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(I) bromide dimethylsulfide complex / hexane; tetrahydrofuran / 0.25 h / -30 °C

1.2: 1.5 h / -30 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / 0 °C

3.1: pyridine / 15 h / 0 °C

With pyridine; copper(I) bromide dimethylsulfide complex; diisobutylaluminium hydride; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/jm500392t

Reference yield:

: 1237750-56-9
ethyl (3S)-3-{1-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]ethyl}heptanoate

: 1608457-67-5
(3R)-3-{1-[(1R,3R,7E,17β)-1,3-bis{[tert-butyl(dimethyl)silyl]oxy}-2-methylidene-9,10-secoestra-5,7-dien-17-yl]ethyl}heptyl-4-methyl benzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / 0 °C

2: pyridine / 15 h / 0 °C

With pyridine; diisobutylaluminium hydride; In tetrahydrofuran; toluene;
DOI:10.1021/jm500392t