3-(4-Piperidinyl)-2-oxazolidinone HCl

Base Information

• Chemical Name: 3-(4-Piperidinyl)-2-oxazolidinone HCl
• CAS No.: 130818-98-3
• Molecular Formula: C8H14N2O2.ClH
• Molecular Weight: 206.672
• Mol file: 130818-98-3.mol

Synonyms:3-piperidin-4-yloxazolidin-2-one hydrochloride;3-piperidin-4-yl-oxazolidin-2-one hydrochloride;3-(4-Piperidinyl)-2-oxazolidinone HCl;3-piperidin-4-yl-oxazolidin-2-one hydrochloride salt;

Chemical Property of 3-(4-Piperidinyl)-2-oxazolidinone HCl

Chemical Property:

• PSA: 41.57000
• LogP: 1.25930

Purity/Quality:

99% ^*data from raw suppliers

3-(4-Piperidinyl)-2-oxazolidinoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Piperidinyl)-2-oxazolidinone HCl

There total 4 articles about 3-(4-Piperidinyl)-2-oxazolidinone HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(1-benzylpiperidin-4-yl)oxazolidin-2-one (130818-97-2) → 3-(4-piperidinyl)-1,3-oxazolidin-2-one hydrochloride (130818-98-3)

Guidance literature:

3-(1-benzylpiperidin-4-yl)oxazolidin-2-one; With 4-Chlorobutanoyl chloride; In 1,2-dichloro-ethane; at 100 ℃; for 1.5h;

In methanol; for 1h; Heating / reflux;

Reference yield: 99.0%

tert-butyl 4-(2-ketooxazolidin-3-yl)piperidin-1-carboxylate (1148003-95-5) → 3-(4-piperidinyl)-1,3-oxazolidin-2-one hydrochloride (130818-98-3)

Guidance literature:

With hydrogenchloride; In methanol; ethyl acetate; at 20 - 50 ℃; for 0.5h; Solvent;

Reference yield:

1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → 3-(4-piperidinyl)-1,3-oxazolidin-2-one hydrochloride (130818-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrahydrofuran / 9 h / -10 - 20 °C / Inert atmosphere

1.2: 5 h / -10 - 20 °C

2.1: hydrogenchloride / ethyl acetate; methanol / 0.5 h / 20 - 50 °C

With hydrogenchloride; potassium carbonate; In tetrahydrofuran; methanol; ethyl acetate;

upstream raw materials:

3-(1-benzylpiperidin-4-yl)oxazolidin-2-one

1-(tert-butoxycarbonyl)-4-aminopiperidine

tert-butyl 4-(2-ketooxazolidin-3-yl)piperidin-1-carboxylate

Downstream raw materials:

3-(1-{2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl}piperidin-4-yl)oxazolidin-2-one

3-(1-{2-[4-(benzothiazol-2-yloxy)phenyl]ethyl}piperidin-4-yl)oxazolidin-2-one

Refernces

• 1、 Grice, Cheryl A.,Tays, Kevin L.,Savall, Brad M.,Wei, Jianmei,Butler, Christopher R.,Axe, Frank U.,Bembenek, Scott D.,Fourie, Anne M.,Dunford, Paul J.,Lundeen, Katherine,Coles, Fawn,Xue, Xiaohua,Riley, Jason P.,Williams, Kacy N.,Karlsson, Lars,Edwards, James P.. "Identification of a potent, selective, and orally active leukotriene A 4 hydrolase inhibitor with anti-inflammatory activity". experimental part. p. 4150 - 4169. Retrieved 2009/07/19.