Ethyl-2,3-di-O-benzyl-5-O-tosyl-β-D-galactofuranosid

Base Information

• Chemical Name: Ethyl-2,3-di-O-benzyl-5-O-tosyl-β-D-galactofuranosid
• CAS No.: 88480-97-1
• Molecular Formula: C₂₉H₃₄O₈S
• Molecular Weight: 542.65
• Mol file: 88480-97-1.mol

Synonyms:

Chemical Property of Ethyl-2,3-di-O-benzyl-5-O-tosyl-β-D-galactofuranosid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl-2,3-di-O-benzyl-5-O-tosyl-β-D-galactofuranosid

There total 4 articles about Ethyl-2,3-di-O-benzyl-5-O-tosyl-β-D-galactofuranosid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

ethyl 2,3-di-O-benzyl-β-D-galactofuranoside (76696-18-9) + p-toluenesulfonyl chloride (98-59-9) → Ethyl-2,3-di-O-benzyl-6-O-tosyl-β-D-galactofuranosid (76696-19-0) + Ethyl-5,6-anhydro-2,3-di-O-benzyl-β-D-galactofuranosid (88481-01-0) + Ethyl-2,3-di-O-benzyl-5-O-tosyl-β-D-galactofuranosid (88480-97-1) + Ethyl-2,3-di-O-benzyl-5,6-di-O-tosyl-β-D-galactofuranosid (88480-98-2)

Guidance literature:

With pyridine; In dichloromethane; at -15 ℃; for 20h;

Reference yield:

Ethyl-2,3-di-O-benzyl-5,6-O-isopropyliden-β-D-galactofuranosid (76696-17-8) → Ethyl-2,3-di-O-benzyl-5-O-tosyl-β-D-galactofuranosid (88480-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / acetic acid / H₂O / 1.5 h / 75 °C

2: 1 percent / pyridine / CH₂Cl₂ / 20 h / -15 °C

With pyridine; acetic acid; In dichloromethane; water;

Reference yield:

Ethyl-5,6-O-isopropyliden-β-D-galactofuranosid (76696-16-7) → Ethyl-2,3-di-O-benzyl-5-O-tosyl-β-D-galactofuranosid (88480-97-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) KOH / 1) 2 h, 80 deg C, dioxane, 2) 3 h

2: 64 percent / acetic acid / H₂O / 1.5 h / 75 °C

3: 1 percent / pyridine / CH₂Cl₂ / 20 h / -15 °C

With pyridine; potassium hydroxide; acetic acid; In dichloromethane; water;

upstream raw materials:

ethyl 2,3-di-O-benzyl-β-D-galactofuranoside

p-toluenesulfonyl chloride

Ethyl-2,3-di-O-benzyl-5,6-O-isopropyliden-β-D-galactofuranosid

ethyl-β-D-galactofuranoside

Refernces