1-(4-((2-((7-methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea

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Chemical Name:1-(4-((2-((7-methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea
CAS No.:1571073-69-2
Molecular Formula:C₄₁H₄₄N₁₀O₄Si
Molecular Weight:768.95
Hs Code.:

1-(4-((2-((7-methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea

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Chemical Property of 1-(4-((2-((7-methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea

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Technology Process of 1-(4-((2-((7-methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea

There total 3 articles about 1-(4-((2-((7-methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36960-47-1
ethyl 3-(trimethylsilyl)-1H-pyrazole-5-carboxylate

: 1571073-69-2
1-(4-((2-((7-methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; copper diacetate / dichloromethane / 18 h / 20 °C / Molecular sieve

2.1: sodium hydroxide; ethanol / 4 h / 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 2 h / 100 °C

4.1: toluene-4-sulfonic acid / tetrahydrofuran; N,N-dimethyl-formamide / 60 °C

With pyridine; ethanol; diphenyl phosphoryl azide; copper diacetate; toluene-4-sulfonic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1571073-77-2
ethyl 1-(6-methoxypyridin-3-yl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylate

: 1571073-69-2
1-(4-((2-((7-methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; ethanol / 4 h / 20 °C

2.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2.2: 2 h / 100 °C

3.1: toluene-4-sulfonic acid / tetrahydrofuran; N,N-dimethyl-formamide / 60 °C

With ethanol; diphenyl phosphoryl azide; toluene-4-sulfonic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 476011-71-9
4-(2-chloro-pyrimidin-4-yloxy)-naphthalen-1-ylamine

: 1571073-86-3
1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylic acid

: 1571073-69-2
1-(4-((2-((7-methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(4-(2-morpholinoethoxy)phenyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

1.2: 2 h / 100 °C

2.1: toluene-4-sulfonic acid / tetrahydrofuran; N,N-dimethyl-formamide / 60 °C

With diphenyl phosphoryl azide; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;