(1R)-1-phenylethanaminium (3aS,4R,6R,7R,7aR)-7-chloro-6-hydroxyoctahydro-1H-indene-4-carboxylate

Base Information

Chemical Name:(1R)-1-phenylethanaminium (3aS,4R,6R,7R,7aR)-7-chloro-6-hydroxyoctahydro-1H-indene-4-carboxylate
CAS No.:1258075-76-1
Molecular Formula:C₈H₁₁N*C₁₀H₁₅ClO₃
Molecular Weight:339.862
Hs Code.:

Synonyms:

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Chemical Property of (1R)-1-phenylethanaminium (3aS,4R,6R,7R,7aR)-7-chloro-6-hydroxyoctahydro-1H-indene-4-carboxylate

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Technology Process of (1R)-1-phenylethanaminium (3aS,4R,6R,7R,7aR)-7-chloro-6-hydroxyoctahydro-1H-indene-4-carboxylate

There total 7 articles about (1R)-1-phenylethanaminium (3aS,4R,6R,7R,7aR)-7-chloro-6-hydroxyoctahydro-1H-indene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2409-89-4
methyl (2E,7E)-2,7,9-decatrien-1-oate

: 1258075-76-1
(1R)-1-phenylethanaminium (3aS,4R,6R,7R,7aR)-7-chloro-6-hydroxyoctahydro-1H-indene-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / diethyl ether; toluene / -78 °C / Inert atmosphere

2: manganese(IV) oxide / diethyl ether / 1 h / 20 °C / Inert atmosphere

3: 2,6-dimethylpyridine; [Ru(η5-C8H7)((S,S)-BIPHOP-F)(acetone)][SbF6] / dichloromethane / 168 h / 20 °C / Inert atmosphere

4: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / ter-butanol; water / 1 h / Inert atmosphere

5: Inert atmosphere

With 2,6-dimethylpyridine; manganese(IV) oxide; sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; [Ru(η5-C8H7)((S,S)-BIPHOP-F)(acetone)][SbF6]; diisobutylaluminium hydride; In ter-butanol; diethyl ether; dichloromethane; water; toluene; 3: Diels-Alder reaction / 4: Pinnick oxidation;
DOI:10.1021/ol1019103

Reference yield:

: 74930-36-2
(5E)-5,7-octadienal

: 1258075-76-1
(1R)-1-phenylethanaminium (3aS,4R,6R,7R,7aR)-7-chloro-6-hydroxyoctahydro-1H-indene-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / diethyl ether; toluene / -78 °C / Inert atmosphere

3.1: manganese(IV) oxide / diethyl ether / 1 h / 20 °C / Inert atmosphere

4.1: 2,6-dimethylpyridine; [Ru(η5-C8H7)((S,S)-BIPHOP-F)(acetone)][SbF6] / dichloromethane / 168 h / 20 °C / Inert atmosphere

5.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / ter-butanol; water / 1 h / Inert atmosphere

6.1: Inert atmosphere

With 2,6-dimethylpyridine; manganese(IV) oxide; sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; [Ru(η5-C8H7)((S,S)-BIPHOP-F)(acetone)][SbF6]; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; ter-butanol; diethyl ether; dichloromethane; water; toluene; mineral oil; 4.1: Diels-Alder reaction / 5.1: Pinnick oxidation;
DOI:10.1021/ol1019103

Reference yield:

: 74930-35-1
hepta-4(E),6-dienecarbonitrile

: 1258075-76-1
(1R)-1-phenylethanaminium (3aS,4R,6R,7R,7aR)-7-chloro-6-hydroxyoctahydro-1H-indene-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / diethyl ether; toluene / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / diethyl ether; toluene / -78 °C / Inert atmosphere

4.1: manganese(IV) oxide / diethyl ether / 1 h / 20 °C / Inert atmosphere

5.1: 2,6-dimethylpyridine; [Ru(η5-C8H7)((S,S)-BIPHOP-F)(acetone)][SbF6] / dichloromethane / 168 h / 20 °C / Inert atmosphere

6.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / ter-butanol; water / 1 h / Inert atmosphere

7.1: Inert atmosphere

With 2,6-dimethylpyridine; manganese(IV) oxide; sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; [Ru(η5-C8H7)((S,S)-BIPHOP-F)(acetone)][SbF6]; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; ter-butanol; diethyl ether; dichloromethane; water; toluene; mineral oil; 5.1: Diels-Alder reaction / 6.1: Pinnick oxidation;
DOI:10.1021/ol1019103