Technology Process of 1,5-di-p-tolyl-1,3,5,7-tetrahydroisobenzofuro[5,6-c]furan-1,5-diol
There total 4 articles about 1,5-di-p-tolyl-1,3,5,7-tetrahydroisobenzofuro[5,6-c]furan-1,5-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2,5-diiodo-1,4-phenylene)bis(methylene)bis(4-methylbenzoate);
With
n-butyllithium;
In
tetrahydrofuran;
at -114 - 20 ℃;
Inert atmosphere;
With
ammonium chloride;
In
tetrahydrofuran;
Inert atmosphere;
DOI:10.1039/c0ob00575d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: bromine / ethylene dibromide / 135 °C / Inert atmosphere
2.1: potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran / -114 - 20 °C / Inert atmosphere
3.2: Inert atmosphere
With
n-butyllithium; bromine; potassium carbonate;
In
tetrahydrofuran; ethylene dibromide; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00575d
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuric acid; iodine; acetic acid; potassium iodide / water / 6 h / Inert atmosphere; Reflux
2.1: bromine / ethylene dibromide / 135 °C / Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran / -114 - 20 °C / Inert atmosphere
4.2: Inert atmosphere
With
n-butyllithium; sulfuric acid; bromine; iodine; potassium carbonate; acetic acid; potassium iodide;
In
tetrahydrofuran; water; ethylene dibromide; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00575d
