2,3,5,6-Tetrahydro-5-(3,4-dichlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

Base Information

Chemical Name:2,3,5,6-Tetrahydro-5-(3,4-dichlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol
CAS No.:56882-49-6
Molecular Formula:C₁₇H₁₄Cl₂N₂O
Molecular Weight:333.217
Hs Code.:
DSSTox Substance ID:DTXSID20972316
Nikkaji Number:J61.474B
ChEMBL ID:CHEMBL164017

Synonyms:BRN 0694307;56882-49-6;2,3,5,6-Tetrahydro-5-(3,4-dichlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol;5-(3,4-Dichlorophenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol;Imidazo(2,1-a)isoquinolin-5-ol, 2,3,5,6-tetrahydro-5-(3,4-dichlorophenyl)-;CHEMBL164017;SCHEMBL9693958;DTXSID20972316;LS-77911

Suppliers and Price of 2,3,5,6-Tetrahydro-5-(3,4-dichlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2,3,5,6-Tetrahydro-5-(3,4-dichlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

Chemical Property:

Vapor Pressure:1.33E-10mmHg at 25°C
Boiling Point:494.7°C at 760 mmHg
Flash Point:253°C
PSA：35.83000
Density:1.45g/cm³
LogP:2.83050
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:332.0483185
Heavy Atom Count:22
Complexity:472

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN2C(=N1)C3=CC=CC=C3CC2(C4=CC(=C(C=C4)Cl)Cl)O

Technology Process of 2,3,5,6-Tetrahydro-5-(3,4-dichlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

There total 4 articles about 2,3,5,6-Tetrahydro-5-(3,4-dichlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51-44-5
3,4-dichlorbenzoic acid

: 56882-49-6
5-(3,4-dichlorophenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂ / 5 h / Heating

2: benzene; methanol / Ambient temperature

3: 1.) n-BuLi / 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h

With n-butyllithium; thionyl chloride; In methanol; dichloromethane; benzene;
DOI:10.1021/jm00359a025

Reference yield:

: 3024-72-4
3,4-dichlorobenzoyl chloride

: 56882-49-6
5-(3,4-dichlorophenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: Multi-step reaction with 2 steps

1: benzene; methanol / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h

With n-butyllithium; In methanol; benzene;
DOI:10.1021/jm00359a025

Reference yield:

: 28394-58-3
3,4-dichloro-benzoic acid ethyl ester

: 57327-93-2
2-(o-Tolyl)-2-imidazoline

: 56882-49-6
5-(3,4-dichlorophenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h;
DOI:10.1021/jm00359a025