(+/-)-dihydroisocodeine

Base Information

• Chemical Name: (+/-)-dihydroisocodeine
• CAS No.: 144408-29-7
• Molecular Formula: C₁₈H₂₃NO₃
• Molecular Weight: 301.386
• Mol file: 144408-29-7.mol

Synonyms:

Chemical Property of (+/-)-dihydroisocodeine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-dihydroisocodeine

There total 52 articles about (+/-)-dihydroisocodeine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(+/-)-dihydrocodeinone (74035-75-9) → (+/-)-dihydrocodeine (125-28-0,795-38-0,28379-49-9,29699-74-9,144408-29-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.75h;

DOI:10.1039/c7sc03189k

Reference yield: 70.0%

N-[2-(3-hydroxy-5-methoxy-1,3,3a,9a-tetrahydro-2H-phenanthro[4,5-bcd]furan-9b-yl)-ethyl]-4,N-dimethyl-benzenesulfonamide → (+/-)-dihydrocodeine (125-28-0,795-38-0,28379-49-9,29699-74-9,144408-29-7)

Guidance literature:

With ammonia; lithium; In tetrahydrofuran; tert-butyl alcohol; at -78 ℃; for 0.166667h;

DOI:10.1021/jo0513008

Reference yield:

→ 4,5-epoxy-3-methoxy-17-methyl-morphinan-6-ol (125-28-0,795-38-0,28379-49-9,29699-74-9,144408-29-7)

Guidance literature:

Dihydrothebain, HCl, Δ;

upstream raw materials:

2-Bromo-6-methoxy-3-((E)-2-phenylsulfanyl-vinyl)-phenol

6-bromoguaiacol

2-(5-methoxy-cyclohexa-1,4-dienyl)-ethylamine

N-[2-((1S,5S,6S)-5-Hydroxy-7-oxa-bicyclo[4.1.0]hept-1-yl)-ethyl]-4,N-dimethyl-benzenesulfonamide