C₁₆H₁₄F₂N₄O₄S

Base Information

• Chemical Name: C₁₆H₁₄F₂N₄O₄S
• CAS No.: 1375830-56-0
• Molecular Formula: C₁₆H₁₄F₂N₄O₄S
• Molecular Weight: 396.374
• Mol file: 1375830-56-0.mol

Synonyms:

Chemical Property of C₁₆H₁₄F₂N₄O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₄F₂N₄O₄S

There total 3 articles about C₁₆H₁₄F₂N₄O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-difluorobenzylamine (72235-53-1) + methyl [6-(chlorosulfonyl)-1H-benzo[d]imidazol-2-yl]-carbamate (79213-74-4) → C16H14F2N4O4S (1375830-56-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2012.03.042

Reference yield:

1H-benzimidazol-2-ylcarbamic acid methyl ester (162976-69-4,102040-01-7,110342-67-1,212384-28-6,276680-08-1,63090-40-4,63278-70-6,59758-95-1) → C16H14F2N4O4S (1375830-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / ethyl acetate / 0 °C

2: triethylamine / tetrahydrofuran / 20 °C

With chlorosulfonic acid; triethylamine; In tetrahydrofuran; ethyl acetate;

DOI:10.1016/j.bmcl.2012.03.042

Reference yield:

1H-benzimidazol-2-amine (934-32-7) → C16H14F2N4O4S (1375830-56-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutylammomium bromide; calcium chloride / 6 h / 90 - 100 °C

2: chlorosulfonic acid / ethyl acetate / 0 °C

3: triethylamine / tetrahydrofuran / 20 °C

With chlorosulfonic acid; tetrabutylammomium bromide; triethylamine; calcium chloride; In tetrahydrofuran; ethyl acetate;

DOI:10.1016/j.bmcl.2012.03.042

upstream raw materials:

1H-benzimidazol-2-amine

1H-benzimidazol-2-ylcarbamic acid methyl ester

3,4-difluorobenzylamine

methyl [6-(chlorosulfonyl)-1H-benzo[d]imidazol-2-yl]-carbamate

Refernces