4-(4-Ethylphenyl)-1,3-thiazol-2-amine

Base Information

• Chemical Name: 4-(4-Ethylphenyl)-1,3-thiazol-2-amine
• CAS No.: 85112-35-2
• Molecular Formula: C11H12 N2 S
• Molecular Weight: 204.296
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID20352699
• Wikidata: Q82129972
• Mol file: 85112-35-2.mol

Synonyms:85112-35-2;4-(4-ethylphenyl)-1,3-thiazol-2-amine;4-(4-Ethyl-phenyl)-thiazol-2-ylamine;4-(4-ethylphenyl)thiazol-2-amine;4-(4-ethylphenyl)thiazol-2-ylamine;MFCD01471496;2-amino-4-(4'-ethylphenyl)-thiazole;CBMicro_032269;MixCom6_001933;Oprea1_047399;CBDivE_009958;SCHEMBL476184;IFLab1_003845;DTXSID20352699;YDFOGNLELPWXHU-UHFFFAOYSA-N;BBL020241;STK410916;AKOS000115507;AB09155;IDI1_009952;MS-10992;BIM-0032159.P001;BB 0218513;EN300-02243;Z48847651;F1386-0388

Chemical Property of 4-(4-Ethylphenyl)-1,3-thiazol-2-amine

Chemical Property:

• Vapor Pressure: 7.62E-06mmHg at 25°C
• Boiling Point: 375.7°C at 760 mmHg
• Flash Point: 181°C
• PSA: 67.15000
• Density: 1.184g/cm³
• LogP: 3.53590
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 204.07211956
• Heavy Atom Count: 14
• Complexity: 178

Purity/Quality:

98%min ^*data from raw suppliers

4-(4-Ethyl-phenyl)-thiazol-2-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC=C(C=C1)C2=CSC(=N2)N

Technology Process of 4-(4-Ethylphenyl)-1,3-thiazol-2-amine

There total 4 articles about 4-(4-Ethylphenyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-ethylacetophenone (937-30-4) + thiourea (17356-08-0) → 2-amino-4-(4'-ethylphenyl)-thiazole (85112-35-2)

Guidance literature:

With iodine; at 100 ℃; for 8h;

DOI:10.1016/j.bmcl.2014.10.030

Reference yield:

4-ethylacetophenone (937-30-4) → 2-amino-4-(4'-ethylphenyl)-thiazole (85112-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; citric acid / ethanol; water / 0.33 h / Reflux

2: Reflux

With N-Bromosuccinimide; citric acid; In ethanol; water;

DOI:10.1002/jccs.201700200

Reference yield:

4-ethylphenacyl bromide (2632-14-6) + thiourea (17356-08-0) → 2-amino-4-(4'-ethylphenyl)-thiazole (85112-35-2)

Guidance literature:

Reflux;

DOI:10.1002/jccs.201700200

upstream raw materials:

4-ethylacetophenone

thiourea

4-ethylphenacyl bromide

Downstream raw materials:

C₂₇H₂₁N₃OS

C₁₆H₁₉N₃O₃S

N-[4-(4-ethylphenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl)acetamide

2-{bis-[4-(4-ethyl-phenyl)-thiazol-2-ylamino]-methyl}-phenol

Refernces

• 1、 Rodrigues, Carina Agostinho,dos Santos, Paloma Freire,da Costa, Marcela Oliveira Legramanti,Pavani, Thais Fernanda Amorim,Xander, Patrícia,Geraldo, Mariana Marques,Mengarda, Ana,de Moraes, Josué,Rando, Daniela Gon?ales Galasse. "4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents". . . Retrieved 2018/09/13.
• 2、 Koppireddi, Satish,Chilaka, Deepika Raj Kumari,Avula, Sreenivas,Komsani, Jayaram Reddy,Kotamraju, Srigiridhar,Yadla, Rambabu. "Synthesis and anticancer evaluation of 3-aryl-6-phenylimidazo[2,1-b]thiazoles". supporting information. p. 5428 - 5431. Retrieved 2015/01/08.