trans-2,5-Dimethylpyrrolidine Hydrochloride

Base Information

• Chemical Name: trans-2,5-Dimethylpyrrolidine Hydrochloride
• CAS No.: 4209-65-8
• Molecular Formula: C₆H₁₃N*ClH
• Molecular Weight: 135.637
• Mol file: 4209-65-8.mol

Synonyms:

Chemical Property of trans-2,5-Dimethylpyrrolidine Hydrochloride

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

(2S,5R)-2,5-dimethylpyrrolidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-2,5-Dimethylpyrrolidine Hydrochloride

There total 14 articles about trans-2,5-Dimethylpyrrolidine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-aminohex-5-ene (7380-76-9,73604-43-0) → trans-2,5-Dimethylpyrrolidine Hydrochloride (4209-65-8,4832-49-9,63639-02-1,70144-18-2,114143-75-8,138133-34-3)

Guidance literature:

2-aminohex-5-ene; With 1,3-bis(2-iPrC₆H₄)-2-bis(TMS)N-2,1,3-scandiadiazolidine; In benzene; at 60 ℃; for 3h;

With hydrogenchloride; In diethyl ether; benzene; at -15 ℃;

DOI:10.1021/ol051574h

Reference yield: 90.0%

(2S)-2-(2R,5S)-2,5-dimethyltetrahydro-1H-1-pyrrolyl-2-phenylethan-1-ol (205442-92-8) → (2R,5S)-2,5-dimethyltetrahydro-1H-1-pyrrolylidium chloride (4209-65-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 24h; under 2068.59 Torr;

DOI:10.1021/jo9821426

Reference yield: 80.0%

trans-N-(Carbobenzyloxy)-2,5-dimethylpyrrolidine (78329-37-0) → trans-2,5-Dimethylpyrrolidine Hydrochloride (4209-65-8,4832-49-9,63639-02-1,70144-18-2,114143-75-8,138133-34-3)

Guidance literature:

With hydrogenchloride; In acetic acid;

DOI:10.1021/jo00332a036

upstream raw materials:

(2S,5R)-2,5-Dimethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S)-2-(2R,5S)-2,5-dimethyltetrahydro-1H-1-pyrrolyl-2-phenylethan-1-ol

2,5-Dimethylpyrrole

1-<(1,1-dimethylethoxy)carbonyl>-2,5-dimethylpyrrole

Downstream raw materials:

2,5-dimethyl-1-(phenylethynyl)-pyrrolidine