(2R,3S)-4-methoxy-3-(3-nitrobenzamido)-4-oxobutan-2-yl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Base Information

• Chemical Name: (2R,3S)-4-methoxy-3-(3-nitrobenzamido)-4-oxobutan-2-yl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
• CAS No.: 1394961-63-7
• Molecular Formula: C₃₇H₃₇N₃O₈
• Molecular Weight: 651.716
• Mol file: 1394961-63-7.mol

Synonyms:

Chemical Property of (2R,3S)-4-methoxy-3-(3-nitrobenzamido)-4-oxobutan-2-yl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-4-methoxy-3-(3-nitrobenzamido)-4-oxobutan-2-yl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

There total 2 articles about (2R,3S)-4-methoxy-3-(3-nitrobenzamido)-4-oxobutan-2-yl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3R)-methyl 2-(3-nitrobenzamido)-3-(3-oxobutanoyloxy)-butanoate (1394961-61-5) + dimedone (126-81-8) + 4-Phenylbenzaldehyde (3218-36-8) → (2R,3S)-4-methoxy-3-(3-nitrobenzamido)-4-oxobutan-2-yl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (1394961-63-7)

Guidance literature:

With ammonium acetate; iodine; In ethanol; at 20 ℃; for 20h;

DOI:10.1021/jm301144g

Reference yield:

(2S,3R)-methyl 3-hydroxy-2-(3-nitrobenzamido)butanoate (1408382-87-5) → (2R,3S)-4-methoxy-3-(3-nitrobenzamido)-4-oxobutan-2-yl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (1394961-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / tetrahydrofuran / 20 °C

2: ammonium acetate; iodine / ethanol / 20 h / 20 °C

With dmap; ammonium acetate; iodine; In tetrahydrofuran; ethanol;

DOI:10.1021/jm301144g

Reference yield:

(2R,3S)-4-methoxy-3-(3-nitrobenzamido)-4-oxobutan-2-yl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (1394961-63-7) → 4-([1,1’-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid (1394961-64-8,1394961-65-9,1408382-80-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; at 20 ℃; for 3h;

DOI:10.1021/jm301144g

upstream raw materials:

(2S,3R)-methyl 2-(3-nitrobenzamido)-3-(3-oxobutanoyloxy)-butanoate

dimedone

4-Phenylbenzaldehyde

(2S,3R)-methyl 3-hydroxy-2-(3-nitrobenzamido)butanoate

Downstream raw materials:

4-([1,1’-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid