(2R,4R,8R,9R,10S,11S,12(2S,5S(2R,5S(R))))-1-((1,1-dimethylethyl)diphenylsiloxy)-9,11-((1-methylethylidene)dioxy)-2,4,8,10-tetramethyl-12-(tetrahydro-5-methyl-5-(tetrahydro-5-(1-((1,1-dimethylethyl)dimethylsiloxy)ethyl)-5-methyl-2-furanyl)-2-furanyl)-...

Base Information

• Chemical Name: (2R,4R,8R,9R,10S,11S,12(2S,5S(2R,5S(R))))-1-((1,1-dimethylethyl)diphenylsiloxy)-9,11-((1-methylethylidene)dioxy)-2,4,8,10-tetramethyl-12-(tetrahydro-5-methyl-5-(tetrahydro-5-(1-((1,1-dimethylethyl)dimethylsiloxy)ethyl)-5-methyl-2-furanyl)-2-furanyl)-...
• CAS No.: 128329-88-4
• Molecular Formula: C₅₃H₈₈O₆Si₂
• Molecular Weight: 877.449

Synonyms:

Chemical Property of (2R,4R,8R,9R,10S,11S,12(2S,5S(2R,5S(R))))-1-((1,1-dimethylethyl)diphenylsiloxy)-9,11-((1-methylethylidene)dioxy)-2,4,8,10-tetramethyl-12-(tetrahydro-5-methyl-5-(tetrahydro-5-(1-((1,1-dimethylethyl)dimethylsiloxy)ethyl)-5-methyl-2-furanyl)-2-furanyl)-...

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4R,8R,9R,10S,11S,12(2S,5S(2R,5S(R))))-1-((1,1-dimethylethyl)diphenylsiloxy)-9,11-((1-methylethylidene)dioxy)-2,4,8,10-tetramethyl-12-(tetrahydro-5-methyl-5-(tetrahydro-5-(1-((1,1-dimethylethyl)dimethylsiloxy)ethyl)-5-methyl-2-furanyl)-2-furanyl)-...

There total 35 articles about (2R,4R,8R,9R,10S,11S,12(2S,5S(2R,5S(R))))-1-((1,1-dimethylethyl)diphenylsiloxy)-9,11-((1-methylethylidene)dioxy)-2,4,8,10-tetramethyl-12-(tetrahydro-5-methyl-5-(tetrahydro-5-(1-((1,1-dimethylethyl)dimethylsiloxy)ethyl)-5-methyl-2-furanyl)-2-furanyl)-... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C61H96O10SSi2 (128329-87-3) → (2R,4R,8R,9R,10S,11S,12(2S,5S(2R,5S(R))))-1-((1,1-dimethylethyl)diphenylsiloxy)-9,11-((1-methylethylidene)dioxy)-2,4,8,10-tetramethyl-12-(tetrahydro-5-methyl-5-(tetrahydro-5-(1-((1,1-dimethylethyl)dimethylsiloxy)ethyl)-5-methyl-2-furanyl)-2-furanyl)-... (128329-88-4,128440-52-8)

Guidance literature:

With sodium amalgam; In methanol; ethyl acetate; at -30 ℃; for 20h; Yield given;

DOI:10.1021/ja00169a042

Reference yield:

(2R,3R,4S)-1-(benzyloxy)-2,4-dimethyl-3,5,6-hexanetriol (128329-68-0,128440-44-8) → (2R,4R,8R,9R,10S,11S,12(2S,5S(2R,5S(R))))-1-((1,1-dimethylethyl)diphenylsiloxy)-9,11-((1-methylethylidene)dioxy)-2,4,8,10-tetramethyl-12-(tetrahydro-5-methyl-5-(tetrahydro-5-(1-((1,1-dimethylethyl)dimethylsiloxy)ethyl)-5-methyl-2-furanyl)-2-furanyl)-... (128329-88-4,128440-52-8)

Guidance literature:

Multi-step reaction with 13 steps

1: 2.01 g / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / 25 °C

2: 2.13 g / 2,2-dimethoxypropane, d,l-camphorsulfonic acid / 2 h / 25 °C

3: 1 N Bu₄NF / tetrahydrofuran / 10 h / 25 °C

4: 95 percent / triethylamine, SO₃*pyridine / dimethylsulfoxide / 0.75 h / 25 °C

5: 1.) sodium bis(trimethylsilyl)amide / 1.) toluene, 20 deg C, 15 min, 2a.) -78 deg C, 15 min, 2b.) 20 deg C, 30 min

6: 94 percent / Bu₄NF / tetrahydrofuran / 36 h / 80 °C

7: 1.) mercuric acetate, 2.) NaBH₄, 15percent aq. NaOH / 1.) CH₂Cl₂, 20 deg C, 7 h, 2.) MeOH, 20 deg C, 30 min

8: 100 percent / triethylamine / CH₂Cl₂ / 1.5 h / 0 °C

9: 94 percent / H₂ / 10percent Pd/C / acetone / 3 h / 20 °C / 760 Torr

10: oxalyl chloride, DMSO / CH₂Cl₂ / 0.5 h / -78 °C

11: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 30 min, 2.) -78 deg C, 1 h

12: tetrahydrofuran; hexane / 1.5 h / 25 °C

13: sodium amalgam / methanol; ethyl acetate / 20 h / -30 °C

With dmap; sodium hydroxide; sodium tetrahydroborate; sodium amalgam; n-butyllithium; oxalyl dichloride; pyridine-SO₃ complex; camphor-10-sulfonic acid; mercury(II) diacetate; tetrabutyl ammonium fluoride; hydrogen; sodium hexamethyldisilazane; dimethyl sulfoxide; triethylamine; 2,2-dimethoxy-propane; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetone;

DOI:10.1021/ja00169a042

Reference yield:

(3R,4S)-1-(benzyloxy)-3-hydroxy-4-(hydroxymethyl)-2-methyl-5-hexene (73814-77-4,108814-34-2) → (2R,4R,8R,9R,10S,11S,12(2S,5S(2R,5S(R))))-1-((1,1-dimethylethyl)diphenylsiloxy)-9,11-((1-methylethylidene)dioxy)-2,4,8,10-tetramethyl-12-(tetrahydro-5-methyl-5-(tetrahydro-5-(1-((1,1-dimethylethyl)dimethylsiloxy)ethyl)-5-methyl-2-furanyl)-2-furanyl)-... (128329-88-4,128440-52-8)

Guidance literature:

Multi-step reaction with 16 steps

1: 0.908 g / pyridine / 18 h / 5 °C

2: 0.468 g / lithium triethylborohydride / tetrahydrofuran / 24 h / 25 °C

3: 1.30 g / N-methylmorpholine N-oxide monohydrate, 0.16 M aq. osmium tetraoxide / acetone / 10 h / 25 °C

4: 2.01 g / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / 25 °C

5: 2.13 g / 2,2-dimethoxypropane, d,l-camphorsulfonic acid / 2 h / 25 °C

6: 1 N Bu₄NF / tetrahydrofuran / 10 h / 25 °C

7: 95 percent / triethylamine, SO₃*pyridine / dimethylsulfoxide / 0.75 h / 25 °C

8: 1.) sodium bis(trimethylsilyl)amide / 1.) toluene, 20 deg C, 15 min, 2a.) -78 deg C, 15 min, 2b.) 20 deg C, 30 min

9: 94 percent / Bu₄NF / tetrahydrofuran / 36 h / 80 °C

10: 1.) mercuric acetate, 2.) NaBH₄, 15percent aq. NaOH / 1.) CH₂Cl₂, 20 deg C, 7 h, 2.) MeOH, 20 deg C, 30 min

11: 100 percent / triethylamine / CH₂Cl₂ / 1.5 h / 0 °C

12: 94 percent / H₂ / 10percent Pd/C / acetone / 3 h / 20 °C / 760 Torr

13: oxalyl chloride, DMSO / CH₂Cl₂ / 0.5 h / -78 °C

14: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 30 min, 2.) -78 deg C, 1 h

15: tetrahydrofuran; hexane / 1.5 h / 25 °C

16: sodium amalgam / methanol; ethyl acetate / 20 h / -30 °C

With pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; sodium amalgam; osmium(VIII) oxide; n-butyllithium; oxalyl dichloride; pyridine-SO₃ complex; camphor-10-sulfonic acid; mercury(II) diacetate; tetrabutyl ammonium fluoride; hydrogen; sodium hexamethyldisilazane; lithium triethylborohydride; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; 2,2-dimethoxy-propane; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetone;

DOI:10.1021/ja00169a042

upstream raw materials:

C₆₁H₉₆O₁₀SSi₂

(4R,6E)-2,4-dimethyl-7-phenyl-6-hepten-1-ol

(4R,6E)-2,4-dimethyl-7-phenyl-6-heptenoic acid

(2R,3R,4S)-1-(benzyloxy)-2,4-dimethyl-3,5,6-hexanetriol

Downstream raw materials:

ionomycin

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 128329-88-4 (2R,4R,8R,9R,10S,11S,12(2S,5S(2R,5S(R))))-1-((1,1-dimethylethyl)diphenylsiloxy)-9,11-((1-methylethylidene)dioxy)-2,4,8,10-tetramethyl-12-(tetrahydro-5-methyl-5-(tetrahydro-5-(1-((1,1-dimethylethyl)dimethylsiloxy)ethyl)-5-methyl-2-furanyl)-2-furanyl)-...

Send

Send

Metric Ton KG G Pound L ML

Send

Send