N-[(S)-2-Cyclohexyl-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

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Chemical Name:N-[(S)-2-Cyclohexyl-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide
CAS No.:128901-48-4
Molecular Formula:C₃₆H₄₅N₇O₃
Molecular Weight:623.798
Hs Code.:

N-[(S)-2-Cyclohexyl-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

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Chemical Property of N-[(S)-2-Cyclohexyl-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

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Technology Process of N-[(S)-2-Cyclohexyl-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

There total 8 articles about N-[(S)-2-Cyclohexyl-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 125816-10-6
<3S-<3α,5β(R^*)>>-5-(2-Cyclohexyl-1-aminoethyl)dihydro-3-isopropyl-2(3H)-furanone

: 128901-34-8
Sodium; 2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionate

: 128901-48-4,128948-73-2,130321-45-8
N-[(S)-2-Cyclohexyl-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a006

Reference yield:

: 128901-46-2
(E)-1-chloro-4-cyclohexyl-2-butene

: 128901-48-4,128948-73-2,130321-45-8
N-[(S)-2-Cyclohexyl-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / NaI / acetone

2: 1.) LDA / 1.) hexane, THF, -40 deg C, 0.5 h, 2.) 0 deg C, 1 h

3: 97 percent / N-bromosuccinimide / H₂O; 1,2-dimethoxy-ethane / 0.17 h / 0 °C

4: NaN₃, DMPU

5: 100 percent / H₂ / 10percent Pd/C / ethanol / 20 °C / 760 Torr

6: 69 percent / 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / H₂O; dimethylformamide

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N-Bromosuccinimide; sodium azide; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; lithium diisopropyl amide; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00171a006

Reference yield:

: 145589-03-3,104266-90-2
(S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one

: 128901-48-4,128948-73-2,130321-45-8
N-[(S)-2-Cyclohexyl-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA / 1.) hexane, THF, -40 deg C, 0.5 h, 2.) 0 deg C, 1 h

2: 97 percent / N-bromosuccinimide / H₂O; 1,2-dimethoxy-ethane / 0.17 h / 0 °C

3: NaN₃, DMPU

4: 100 percent / H₂ / 10percent Pd/C / ethanol / 20 °C / 760 Torr

5: 69 percent / 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / H₂O; dimethylformamide

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N-Bromosuccinimide; sodium azide; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a006