2-[(4-Chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine; hydrochloride

Base Information

• Chemical Name: 2-[(4-Chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine; hydrochloride
• CAS No.: 93852-01-8
• Molecular Formula: C₁₈H₂₀ClNO₃*ClH
• Molecular Weight: 370.276
• Mol file: 93852-01-8.mol

Synonyms:

Chemical Property of 2-[(4-Chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(4-Chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine; hydrochloride

There total 8 articles about 2-[(4-Chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-[1-(4-Chloro-phenyl)-1-(2-methoxy-phenoxy)-ethyl]-morpholin-3-one → 2-[(4-Chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine; hydrochloride (93852-01-8,93852-49-4)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; for 20h; Yield given; Ambient temperature;

Reference yield:

(4-Chloro-phenyl)-(2-methoxy-phenoxy)-acetaldehyde → 2-[(4-Chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine; hydrochloride (93852-01-8,93852-49-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

2: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

3: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

4: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

5: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

With potassium cyanide; sodium metabisulfite; lithium aluminium tetrahydride; potassium tert-butylate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; tert-butyl alcohol;

Reference yield:

(4-Chloro-phenyl)-(2-methoxy-phenoxy)-acetic acid (93853-23-7) → 2-[(4-Chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine; hydrochloride (93852-01-8,93852-49-4)

Guidance literature:

Multi-step reaction with 7 steps

1: SOCl₂ / 16 h / Ambient temperature

2: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

3: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

4: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

5: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

6: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

7: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

With potassium cyanide; sodium metabisulfite; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; lithium tri-t-butoxyaluminum hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; dichloromethane; diethylene glycol dimethyl ether; toluene; tert-butyl alcohol;

upstream raw materials:

(4-Chloro-phenyl)-(2-methoxy-phenoxy)-acetic acid

3-Amino-1-(4-chloro-phenyl)-1-(2-methoxy-phenoxy)-propan-2-ol

(4-Chloro-phenyl)-(2-methoxy-phenoxy)-acetic acid ethyl ester