(R)-Methoxy-phenyl-acetic acid (2R,2aS,3R,5aS,8aS,8bS)-2-methoxy-6,6,8b-trimethyl-2a,3,5a,6,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-yl ester

Base Information

• Chemical Name: (R)-Methoxy-phenyl-acetic acid (2R,2aS,3R,5aS,8aS,8bS)-2-methoxy-6,6,8b-trimethyl-2a,3,5a,6,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-yl ester
• CAS No.: 161551-80-0
• Molecular Formula: C₂₄H₃₂O₅
• Molecular Weight: 400.515
• Mol file: 161551-80-0.mol

Synonyms:

Chemical Property of (R)-Methoxy-phenyl-acetic acid (2R,2aS,3R,5aS,8aS,8bS)-2-methoxy-6,6,8b-trimethyl-2a,3,5a,6,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-Methoxy-phenyl-acetic acid (2R,2aS,3R,5aS,8aS,8bS)-2-methoxy-6,6,8b-trimethyl-2a,3,5a,6,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-yl ester

There total 1 articles about (R)-Methoxy-phenyl-acetic acid (2R,2aS,3R,5aS,8aS,8bS)-2-methoxy-6,6,8b-trimethyl-2a,3,5a,6,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-methoxyphenylacetic acid (3966-32-3) + (2S,2aR,3S,5aR,8aR,8bR)-2-Methoxy-6,6,8b-trimethyl-2a,3,5a,6,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-ol → (R)-Methoxy-phenyl-acetic acid (2S,2aS,3S,5aR,8aR,8bR)-2-methoxy-6,6,8b-trimethyl-2a,3,5a,6,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-yl ester + (R)-Methoxy-phenyl-acetic acid (2R,2aS,3R,5aS,8aS,8bS)-2-methoxy-6,6,8b-trimethyl-2a,3,5a,6,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-yl ester (161551-80-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 3h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1080/00397919408010600

Reference yield:

(R)-Methoxy-phenyl-acetic acid (2R,2aS,3R,5aS,8aS,8bS)-2-methoxy-6,6,8b-trimethyl-2a,3,5a,6,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-yl ester (161551-80-0) → (R)-Methoxy-phenyl-acetic acid (2R,2aS,3S,5aS,8aS,8bS)-4,5-dihydroxy-2-methoxy-6,6,8b-trimethyl-decahydro-naphtho[1,8-bc]furan-3-yl ester

Guidance literature:

With pyridine; osmium(VIII) oxide; In tetrahydrofuran; for 38h; Ambient temperature;

DOI:10.1080/00397919408010600

Reference yield:

(R)-Methoxy-phenyl-acetic acid (2R,2aS,3R,5aS,8aS,8bS)-2-methoxy-6,6,8b-trimethyl-2a,3,5a,6,7,8,8a,8b-octahydro-2H-naphtho[1,8-bc]furan-3-yl ester (161551-80-0) → (R)-Methoxy-phenyl-acetic acid (3aS,5R,5aS,6S,6aS,9aS,9bS,9cS)-5-methoxy-1,1,8,8,9c-pentamethyl-decahydro-4,7,9-trioxa-cyclopenta[e]acenaphthylen-6-yl ester (161551-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 115 mg / osmium tetraoxide, pyridine / tetrahydrofuran / 38 h / Ambient temperature

2: 29.4 percent / p-TsOH / 20 h / Ambient temperature

With pyridine; osmium(VIII) oxide; toluene-4-sulfonic acid; In tetrahydrofuran;

DOI:10.1080/00397919408010600

upstream raw materials:

(R)-methoxyphenylacetic acid

Downstream raw materials:

(R)-Methoxy-phenyl-acetic acid (3aS,5R,5aS,6S,6aS,9aS,9bS,9cS)-5-methoxy-1,1,8,8,9c-pentamethyl-decahydro-4,7,9-trioxa-cyclopenta[e]acenaphthylen-6-yl ester

(R)-Methoxy-phenyl-acetic acid (3aS,5R,5aS,6S,6aR,9aR,9bS,9cS)-5-methoxy-1,1,8,8,9c-pentamethyl-decahydro-4,7,9-trioxa-cyclopenta[e]acenaphthylen-6-yl ester