N-hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide

Base Information

• Chemical Name: N-hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide
• CAS No.: 1433543-71-5
• Molecular Formula: C₁₁H₁₆N₂O₅S
• Molecular Weight: 288.324
• Mol file: 1433543-71-5.mol

Synonyms:

Chemical Property of N-hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide

There total 5 articles about N-hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H17NO5S (1433545-75-5) → N-hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide (1433543-71-5)

Guidance literature:

With hydroxylamine hydrochloride; potassium hydroxide; In methanol; at 80 ℃; for 0.1h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/ml300446a

Reference yield:

4-methoxyphenethyl bromide (14425-64-0) → N-hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide (1433543-71-5)

Guidance literature:

Multi-step reaction with 4 steps

1: tetra-(n-butyl)ammonium iodide; sodium sulfite / ethanol; water / Reflux

2: thionyl chloride / N,N-dimethyl-formamide / 0 - 20 °C

3: triethylamine; dmap / dichloromethane / 0 - 20 °C

4: hydroxylamine hydrochloride; potassium hydroxide / methanol / 0.1 h / 80 °C / Inert atmosphere; Microwave irradiation

With dmap; thionyl chloride; hydroxylamine hydrochloride; tetra-(n-butyl)ammonium iodide; triethylamine; potassium hydroxide; sodium sulfite; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ml300446a

Reference yield:

2-(4-Methoxyphenyl)ethanol (702-23-8) → N-hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide (1433543-71-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; triphenylphosphine; tetrabutylammomium bromide / dichloromethane / 12 h / 20 °C

2: tetra-(n-butyl)ammonium iodide; sodium sulfite / ethanol; water / Reflux

3: thionyl chloride / N,N-dimethyl-formamide / 0 - 20 °C

4: triethylamine; dmap / dichloromethane / 0 - 20 °C

5: hydroxylamine hydrochloride; potassium hydroxide / methanol / 0.1 h / 80 °C / Inert atmosphere; Microwave irradiation

With dmap; thionyl chloride; hydroxylamine hydrochloride; tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; sodium sulfite; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ml300446a

upstream raw materials:

2-(4-Methoxyphenyl)ethanol

4-methoxyphenethyl bromide

sodium 4-methoxy-β-phenethylsulfonate

4-methoxy-β-phenethylsulfonyl chloride