(R,S)-N-(Glycyl-N-benzylvalyl)-aminomethanphosphonsaeure

Base Information

• Chemical Name: (R,S)-N-(Glycyl-N-benzylvalyl)-aminomethanphosphonsaeure
• CAS No.: 90476-49-6
• Molecular Formula: C₁₅H₂₄N₃O₅P
• Molecular Weight: 357.346
• Mol file: 90476-49-6.mol

Synonyms:

Chemical Property of (R,S)-N-(Glycyl-N-benzylvalyl)-aminomethanphosphonsaeure

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,S)-N-(Glycyl-N-benzylvalyl)-aminomethanphosphonsaeure

There total 3 articles about (R,S)-N-(Glycyl-N-benzylvalyl)-aminomethanphosphonsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzylamine (100-46-9) → (R,S)-N-(Glycyl-N-benzylvalyl)-aminomethanphosphonsaeure (90476-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / methanol / 1.) 1 h, room temp., 2.) 8 h, 60 deg C

2: 1.) I₂, (CH₃)3Si-Si(CH₃)3, 2.) MeOH / 1.) CH₂Cl₂, 12 h, room temp. 2.) 2 h, reflux

With methanol; 1,1,1,2,2,2-hexamethyldisilane; iodine; In methanol;

DOI:10.1055/s-1984-30777

Reference yield:

(R,S)-N-(N-Formylglycyl-N-benzylvalyl)-aminomethanphosphonsaeure-diethylester (90476-36-1) → (R,S)-N-(Glycyl-N-benzylvalyl)-aminomethanphosphonsaeure (90476-49-6)

Guidance literature:

With methanol; 1,1,1,2,2,2-hexamethyldisilane; iodine; Yield given. Multistep reaction; 1.) CH₂Cl₂, 12 h, room temp. 2.) 2 h, reflux;

DOI:10.1055/s-1984-30777

Reference yield:

(R,S)-N-(N-Tritylglycyl-N-benzylvalyl)-aminomethanphosphonsaeure-diethylester (90476-46-3) → (R,S)-N-(Glycyl-N-benzylvalyl)-aminomethanphosphonsaeure (90476-49-6)

Guidance literature:

With methanol; 1,1,1,2,2,2-hexamethyldisilane; iodine; Yield given. Multistep reaction; 1.) CH₂Cl₂, 10 h, room temp. 2.) 2 h, reflux;

DOI:10.1055/s-1984-30777

upstream raw materials:

(R,S)-N-(N-Formylglycyl-N-benzylvalyl)-aminomethanphosphonsaeure-diethylester

(R,S)-N-(N-Tritylglycyl-N-benzylvalyl)-aminomethanphosphonsaeure-diethylester

benzylamine