2-methoxy-6-methyl-4-trifluoromethyl-1-benzoic acid

Base Information

Chemical Name:2-methoxy-6-methyl-4-trifluoromethyl-1-benzoic acid
CAS No.:1316831-23-8
Molecular Formula:C₁₀H₉F₃O₃
Molecular Weight:234.175
Hs Code.:

Synonyms:

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Chemical Property of 2-methoxy-6-methyl-4-trifluoromethyl-1-benzoic acid

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Technology Process of 2-methoxy-6-methyl-4-trifluoromethyl-1-benzoic acid

There total 7 articles about 2-methoxy-6-methyl-4-trifluoromethyl-1-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51271-36-4
2,6-dimethoxy-4-trifluoromethyl-benzonitrile

: 1316831-23-8
2-methoxy-6-methyl-4-trifluoromethyl-1-benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide; water / ethanol / 37 h / 20 - 90 °C / Inert atmosphere; oil bath

1.2: 4.5 h / 0 °C / Inert atmosphere

2.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 3 h / 20 - 85 °C / Inert atmosphere; oil bath

3.1: dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4.1: thionyl chloride / dichloromethane / 1 h / 10 - 20 °C

5.1: diethyl ether; tetrahydrofuran / 24 h / 0 - 70 °C / Molecular sieve

5.2: Cooling with ice

6.1: sodium hydrogencarbonate; edetate disodium; Oxone; 1,1,1-trifluoro-2-propanone / acetonitrile / 0.75 h / 20 °C

7.1: sodium hydroxide / 1,4-dioxane; water / 24 h / 100 °C / oil bath

With Oxone; thionyl chloride; 1,1,1-trifluoro-2-propanone; water; edetate disodium; sodium hydrogencarbonate; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1236303-15-3
2,6-Dimethoxy-4-trifluoromethyl-benzoic acid

: 1316831-23-8
2-methoxy-6-methyl-4-trifluoromethyl-1-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 3 h / 20 - 85 °C / Inert atmosphere; oil bath

2.1: dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3.1: thionyl chloride / dichloromethane / 1 h / 10 - 20 °C

4.1: diethyl ether; tetrahydrofuran / 24 h / 0 - 70 °C / Molecular sieve

4.2: Cooling with ice

5.1: sodium hydrogencarbonate; edetate disodium; Oxone; 1,1,1-trifluoro-2-propanone / acetonitrile / 0.75 h / 20 °C

6.1: sodium hydroxide / 1,4-dioxane; water / 24 h / 100 °C / oil bath

With Oxone; thionyl chloride; 1,1,1-trifluoro-2-propanone; edetate disodium; sodium hydrogencarbonate; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1268726-42-6
N-(2-hydroxy-1,1-dimethyl-ethyl)-2,6-dimethoxy-4-trifluoromethyl-benzamide

: 1316831-23-8
2-methoxy-6-methyl-4-trifluoromethyl-1-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / dichloromethane / 1 h / 10 - 20 °C

2.1: diethyl ether; tetrahydrofuran / 24 h / 0 - 70 °C / Molecular sieve

2.2: Cooling with ice

3.1: sodium hydrogencarbonate; edetate disodium; Oxone; 1,1,1-trifluoro-2-propanone / acetonitrile / 0.75 h / 20 °C

4.1: sodium hydroxide / 1,4-dioxane; water / 24 h / 100 °C / oil bath

With Oxone; thionyl chloride; 1,1,1-trifluoro-2-propanone; edetate disodium; sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; acetonitrile;