2-(8-bromo-11-(((6-(2-ethoxy-2-oxoethoxy)-2-methylquinolin-8-yl)amino)methyl)-10-hydroxy-3-oxo-3H-benzo[c]xanthen-7-yl)benzoic acid

Base Information

• Chemical Name: 2-(8-bromo-11-(((6-(2-ethoxy-2-oxoethoxy)-2-methylquinolin-8-yl)amino)methyl)-10-hydroxy-3-oxo-3H-benzo[c]xanthen-7-yl)benzoic acid
• CAS No.: 1333432-90-8
• Molecular Formula: C₃₉H₂₉BrN₂O₈
• Molecular Weight: 733.572
• Mol file: 1333432-90-8.mol

Synonyms:

Chemical Property of 2-(8-bromo-11-(((6-(2-ethoxy-2-oxoethoxy)-2-methylquinolin-8-yl)amino)methyl)-10-hydroxy-3-oxo-3H-benzo[c]xanthen-7-yl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(8-bromo-11-(((6-(2-ethoxy-2-oxoethoxy)-2-methylquinolin-8-yl)amino)methyl)-10-hydroxy-3-oxo-3H-benzo[c]xanthen-7-yl)benzoic acid

There total 4 articles about 2-(8-bromo-11-(((6-(2-ethoxy-2-oxoethoxy)-2-methylquinolin-8-yl)amino)methyl)-10-hydroxy-3-oxo-3H-benzo[c]xanthen-7-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C39H27BrN2O8 → 2-(8-bromo-11-(((6-(2-ethoxy-2-oxoethoxy)-2-methylquinolin-8-yl)amino)methyl)-10-hydroxy-3-oxo-3H-benzo[c]xanthen-7-yl)benzoic acid (1333432-90-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; In methanol; dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ic200986v

Reference yield:

C39H24O7 (679836-10-3) → 2-(8-bromo-11-(((6-(2-ethoxy-2-oxoethoxy)-2-methylquinolin-8-yl)amino)methyl)-10-hydroxy-3-oxo-3H-benzo[c]xanthen-7-yl)benzoic acid (1333432-90-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic acid; 1,1'-azobis(1-cyanocyclohexanenitrile) / chlorobenzene / 168 h / 60 °C

2.1: sodium hydrogencarbonate; dimethyl sulfoxide / 3 h / 140 °C

2.2: 0.5 h / 20 °C

3.1: methanol; dichloromethane / 2 h / 20 °C / Molecular sieve; Darkness

4.1: sodium tris(acetoxy)borohydride / methanol; dichloromethane / 0 - 20 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; dimethyl sulfoxide; 1,1'-azobis(1-cyanocyclohexanenitrile); In methanol; dichloromethane; chlorobenzene; 2.1: Kornblum oxidation;

DOI:10.1021/ic200986v

Reference yield:

8-bromo-11-(bromomethyl)-3'-oxo-3 'H-spiro[benzo[c]xanthene-7,1'-isobenzofuran]-3,10-diyl dibenzoate (1333432-85-1) → 2-(8-bromo-11-(((6-(2-ethoxy-2-oxoethoxy)-2-methylquinolin-8-yl)amino)methyl)-10-hydroxy-3-oxo-3H-benzo[c]xanthen-7-yl)benzoic acid (1333432-90-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; dimethyl sulfoxide / 3 h / 140 °C

1.2: 0.5 h / 20 °C

2.1: methanol; dichloromethane / 2 h / 20 °C / Molecular sieve; Darkness

3.1: sodium tris(acetoxy)borohydride / methanol; dichloromethane / 0 - 20 °C

With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; dimethyl sulfoxide; In methanol; dichloromethane; 1.1: Kornblum oxidation;

DOI:10.1021/ic200986v

upstream raw materials:

8-bromo-11-(bromomethyl)-3'-oxo-3 'H-spiro[benzo[c]xanthene-7,1'-isobenzofuran]-3,10-diyl dibenzoate

2-(11-formyl-10-hydroxy-8-bromo-3-oxo-3H-benzo[c]xanthen-7-yl)benzoic acid

C₃₉H₂₄O₇