3'-Fluoro-4'-(4-oxo-2-propyl-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide

Base Information

• Chemical Name: 3'-Fluoro-4'-(4-oxo-2-propyl-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide
• CAS No.: 1025819-15-1
• Molecular Formula: C₂₆H₂₉FN₄O₃S
• Molecular Weight: 496.606
• Mol file: 1025819-15-1.mol

Synonyms:

Chemical Property of 3'-Fluoro-4'-(4-oxo-2-propyl-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-Fluoro-4'-(4-oxo-2-propyl-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide

There total 1 articles about 3'-Fluoro-4'-(4-oxo-2-propyl-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridine (152460-64-5) + [3-Fluoro-2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl Bromide (159547-21-4) → 3'-Fluoro-4'-(4-oxo-2-propyl-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide (1025819-15-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature; overnight;

DOI:10.1016/S0223-5234(97)84011-1

Reference yield:

3'-Fluoro-4'-(4-oxo-2-propyl-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide (1025819-15-1) → 2-[3-(2'-tert-Butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-4-oxo-2-propyl-3,4-dihydro-imidazo[4,5-c]pyridin-5-yl]-N,N-dimethyl-acetamide (193752-95-3)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1016/S0223-5234(97)84011-1

Reference yield:

3'-Fluoro-4'-(4-oxo-2-propyl-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide (1025819-15-1) → 2-[3-(2'-tert-Butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-4-oxo-2-propyl-3,4-dihydro-imidazo[4,5-c]pyridin-5-yl]-N-(3-methyl-butyl)-acetamide (193753-14-9)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1016/S0223-5234(97)84011-1

upstream raw materials:

4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridine

[3-Fluoro-2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl Bromide

Downstream raw materials:

2-[3-(2'-tert-Butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-4-oxo-2-propyl-3,4-dihydro-imidazo[4,5-c]pyridin-5-yl]-N,N-dimethyl-acetamide

2-[3-(2'-tert-Butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-4-oxo-2-propyl-3,4-dihydro-imidazo[4,5-c]pyridin-5-yl]-N-propyl-acetamide

N-Butyl-2-[3-(2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-4-oxo-2-propyl-3,4-dihydro-imidazo[4,5-c]pyridin-5-yl]-acetamide

N-tert-Butyl-2-[3-(2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-4-oxo-2-propyl-3,4-dihydro-imidazo[4,5-c]pyridin-5-yl]-acetamide