2-(4-(2-(3,4-dimethoxyphenyl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine

Base Information

Chemical Name:2-(4-(2-(3,4-dimethoxyphenyl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine
CAS No.:2180127-82-4
Molecular Formula:C₂₇H₃₇N₃O₂
Molecular Weight:435.61
Hs Code.:

Synonyms:

Suppliers and Price of 2-(4-(2-(3,4-dimethoxyphenyl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of 2-(4-(2-(3,4-dimethoxyphenyl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

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Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-(2-(3,4-dimethoxyphenyl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine

There total 8 articles about 2-(4-(2-(3,4-dimethoxyphenyl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 2180127-82-4
2-(4-(2-(3,4-dimethoxyphenyl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylsilane; trichloroacetic acid / toluene / 1.5 h / 70 °C / Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / tetrahydrofuran; water / 18 h / 75 °C / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / ethyl acetate / 5 h / 25 °C / Inert atmosphere

4.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 0.5 h / 0 °C / Inert atmosphere

5.1: hydrogen bromide; acetic acid / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 0.25 h / 0 - 25 °C / Inert atmosphere

6.2: 1 h / 25 °C / Inert atmosphere

7.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / tetrahydrofuran; water / 18 h / 75 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With triethylsilane; potassium phosphate; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; hydrogen bromide; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; trichloroacetic acid; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; toluene; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acsmedchemlett.0c00264

Reference yield:

: C₁₆H₂₁BrN₂

: 2180127-82-4
2-(4-(2-(3,4-dimethoxyphenyl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.25 h / 0 - 25 °C / Inert atmosphere

1.2: 1 h / 25 °C / Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / tetrahydrofuran; water / 18 h / 75 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/acsmedchemlett.0c00264

Reference yield:

: 439612-51-8
5-bromo-3-isopropyl-1H-indole

: 2180127-82-4
2-(4-(2-(3,4-dimethoxyphenyl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / tetrahydrofuran; water / 18 h / 75 °C / Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / ethyl acetate / 5 h / 25 °C / Inert atmosphere

3.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 0.5 h / 0 °C / Inert atmosphere

4.1: hydrogen bromide; acetic acid / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 0.25 h / 0 - 25 °C / Inert atmosphere

5.2: 1 h / 25 °C / Inert atmosphere

6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / tetrahydrofuran; water / 18 h / 75 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With potassium phosphate; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; hydrogen bromide; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; 1.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acsmedchemlett.0c00264