(S)-6-Benzyloxycarbonylamino-2-[(S)-2-(3-benzyloxycarbonylamino-propionylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester

Base Information

• Chemical Name: (S)-6-Benzyloxycarbonylamino-2-[(S)-2-(3-benzyloxycarbonylamino-propionylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester
• CAS No.: 129797-36-0
• Molecular Formula: C₃₅H₄₂N₄O₈
• Molecular Weight: 646.74
• Mol file: 129797-36-0.mol

Synonyms:

Chemical Property of (S)-6-Benzyloxycarbonylamino-2-[(S)-2-(3-benzyloxycarbonylamino-propionylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-Benzyloxycarbonylamino-2-[(S)-2-(3-benzyloxycarbonylamino-propionylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester

There total 1 articles about (S)-6-Benzyloxycarbonylamino-2-[(S)-2-(3-benzyloxycarbonylamino-propionylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(benzyloxycarbonylamino)propanoic acid (2304-94-1) + phenylalanine-ε-Cbz-lysine methyl ester (129797-35-9) → (S)-6-Benzyloxycarbonylamino-2-[(S)-2-(3-benzyloxycarbonylamino-propionylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester (129797-36-0)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1039/c39900000666

Reference yield:

(S)-6-Benzyloxycarbonylamino-2-[(S)-2-(3-benzyloxycarbonylamino-propionylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester (129797-36-0) → (8S,11S)-8-Benzyl-2,6,9-trioxo-1,3,7,10-tetraaza-cyclopentadecane-11-carboxylic acid

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: Et₃N / toluene

3: LiOH

With lithium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In toluene;

DOI:10.1039/c39900000666

Reference yield:

(S)-6-Benzyloxycarbonylamino-2-[(S)-2-(3-benzyloxycarbonylamino-propionylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester (129797-36-0) → (8S,11S)-8-Benzyl-2,6,9-trioxo-1,3,7,10-tetraaza-cyclopentadecane-11-carboxylic acid methyl ester (129797-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C

2: Et₃N / toluene

With hydrogen; triethylamine; palladium on activated charcoal; In toluene;

DOI:10.1039/c39900000666

upstream raw materials:

3-(benzyloxycarbonylamino)propanoic acid

phenylalanine-ε-Cbz-lysine methyl ester

Downstream raw materials:

(8S,11S)-8-Benzyl-2,6,9-trioxo-1,3,7,10-tetraaza-cyclopentadecane-11-carboxylic acid methyl ester

(8S,11S)-8-Benzyl-2,6,9-trioxo-1,3,7,10-tetraaza-cyclopentadecane-11-carboxylic acid ((1R,2S,3R)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-amide