N-({(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-methyl)-2-benzyl-N'-((S)-1-carbamoyl-3-methyl-butyl)-malonamide; compound with acetic acid

Base Information

Chemical Name:N-({(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-methyl)-2-benzyl-N'-((S)-1-carbamoyl-3-methyl-butyl)-malonamide; compound with acetic acid
CAS No.:123806-01-9
Molecular Formula:C₂H₄O₂*C₂₉H₄₀N₆O₆
Molecular Weight:628.726
Hs Code.:

N-({(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-methyl)-2-benzyl-N'-((S)-1-carbamoyl-3-methyl-butyl)-malonamide; compound with acetic acid

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Chemical Property of N-({(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-methyl)-2-benzyl-N'-((S)-1-carbamoyl-3-methyl-butyl)-malonamide; compound with acetic acid

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Technology Process of N-({(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-methyl)-2-benzyl-N'-((S)-1-carbamoyl-3-methyl-butyl)-malonamide; compound with acetic acid

There total 7 articles about N-({(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-methyl)-2-benzyl-N'-((S)-1-carbamoyl-3-methyl-butyl)-malonamide; compound with acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.5%

: 123709-10-4,123806-00-8
[(S)-1-[(R)-1-({[2-((S)-1-Carbamoyl-3-methyl-butylcarbamoyl)-3-phenyl-propionylamino]-methyl}-carbamoyl)-ethylcarbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

: 123806-01-9,123806-02-0
N-({(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-methyl)-2-benzyl-N'-((S)-1-carbamoyl-3-methyl-butyl)-malonamide; compound with acetic acid

Guidance literature:: With hydrogenchloride; In acetic acid;

Reference yield:

: 2985-39-9,175521-78-5
2-benzylmalonic acid monoethyl ester

: 123806-01-9,123806-02-0
N-({(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-methyl)-2-benzyl-N'-((S)-1-carbamoyl-3-methyl-butyl)-malonamide; compound with acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 92.8 percent / N-methylmorpholine, 1-hydroxybenzotriazole, DCC / tetrahydrofuran / 24 h / Ambient temperature

2: 95 percent / NaOH / H₂O / 0.5 h / Ambient temperature

3: N-methylmorpholine, 1-hydroxybenzotriazole, DCC / dimethylformamide / 24 h / Ambient temperature

4: 81.7 percent / HCl / ethyl acetate

5: 51 percent / N-methylmorpholine, isobutylchloroformate / dimethylformamide; hexamethylphosphoric acid triamide / 2 h / -25 °C

6: 49.5 percent / HCl / acetic acid

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; isobutyl chloroformate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 101854-65-3,101854-66-4
2-Benzyl-N-((S)-1-carbamoyl-3-methyl-butyl)-malonamic acid

: 123806-01-9,123806-02-0
N-({(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-methyl)-2-benzyl-N'-((S)-1-carbamoyl-3-methyl-butyl)-malonamide; compound with acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine, 1-hydroxybenzotriazole, DCC / dimethylformamide / 24 h / Ambient temperature

2: 81.7 percent / HCl / ethyl acetate

3: 51 percent / N-methylmorpholine, isobutylchloroformate / dimethylformamide; hexamethylphosphoric acid triamide / 2 h / -25 °C

4: 49.5 percent / HCl / acetic acid

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; isobutyl chloroformate; In N,N,N,N,N,N-hexamethylphosphoric triamide; acetic acid; ethyl acetate; N,N-dimethyl-formamide;