N-<2-O--glycoloyl>-L-α-aminobutanoyl-D-isoglutamine benzyl ester

Base Information

Chemical Name:N-<2-O--glycoloyl>-L-α-aminobutanoyl-D-isoglutamine benzyl ester
CAS No.:120484-37-9
Molecular Formula:C₄₁H₅₇N₅O₁₆
Molecular Weight:875.927
Hs Code.:

N-<2-O-<benzyl 2-acetamido-4-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2,3-dideoxy-α-D-glucopyranosid-3-yl>-glycoloyl>-L-α-aminobutanoyl-D-isoglutamine benzyl ester

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Chemical Property of N-<2-O--glycoloyl>-L-α-aminobutanoyl-D-isoglutamine benzyl ester

Chemical Property:

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Technology Process of N-<2-O--glycoloyl>-L-α-aminobutanoyl-D-isoglutamine benzyl ester

There total 8 articles about N-<2-O--glycoloyl>-L-α-aminobutanoyl-D-isoglutamine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 120496-14-2
Benzyl 2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-deoxy-3-O-carboxymethyl-α-D-glucopyranoside

: 120484-42-6
L-α-Aminobutanoyl-D-isoglutamine benzyl ester p-toluensulfonate

: 120484-37-9
N-<2-O--glycoloyl>-L-α-aminobutanoyl-D-isoglutamine benzyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

Reference yield:

: 66026-10-6
N-((4aR,6S,7R,8R,8aS)-6-(benzyloxy)-8-hydroxy-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-7-yl)acetamide

: 120484-37-9
N-<2-O--glycoloyl>-L-α-aminobutanoyl-D-isoglutamine benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1) Sodium hydride / 1.) Dioxane, 90 deg C, 2 h, 2.) 65 deg C, 6 h, 3.) ethyl acetate, ether, room temperature, 30 min.

2: 73.6 percent / Dowex 50 (H⁺-form) / methanol / 2 h / Reflux

3: 67 percent / Triethylamine / CH₂Cl₂ / 12 h / 5 °C

4: Silver trifluoromethanesulfonate / CH₂Cl₂ / 1) -45 deg C, 2 h, 2) -20 deg C, 1 h.

5: 0.5M-NaOH / 1) 60 deg C, 3.5 h, 2) methanol, butylamine, 85 deg C, 15 h, sealed ampoule

6: 62 percent / H₂O / 2.5 h / Ambient temperature

7: 33 percent / 1) 1-Hydroxybenzotriazole, 2) N,N'-dicyclohexylcarbodiimide, triethylamine / dimethylformamide / 48 h / Ambient temperature

With sodium hydroxide; Dowex 50 (H⁺-form); silver trifluoromethanesulfonate; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 127528-39-6
Benzyl 2-acetamido-2-deoxy-3-O-(methoxycarbonyl)methyl-α-D-glucopyranoside

: 120484-37-9
N-<2-O--glycoloyl>-L-α-aminobutanoyl-D-isoglutamine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / Triethylamine / CH₂Cl₂ / 12 h / 5 °C

2: Silver trifluoromethanesulfonate / CH₂Cl₂ / 1) -45 deg C, 2 h, 2) -20 deg C, 1 h.

3: 0.5M-NaOH / 1) 60 deg C, 3.5 h, 2) methanol, butylamine, 85 deg C, 15 h, sealed ampoule

4: 62 percent / H₂O / 2.5 h / Ambient temperature

5: 33 percent / 1) 1-Hydroxybenzotriazole, 2) N,N'-dicyclohexylcarbodiimide, triethylamine / dimethylformamide / 48 h / Ambient temperature

With sodium hydroxide; silver trifluoromethanesulfonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; water; N,N-dimethyl-formamide;