(4aS,7S)-7-<2-(4-bromobenzoyloxy)ethyl>-1-(4-methoxy-2,3,6-trimethylbenzenesulfonylimino)-3-methyl-1,2,4a,5,6,7-hexahydropyrrolo<1,2-c>pyrimidine-4-carboxylic acid benzyl ester

Base Information

• Chemical Name: (4aS,7S)-7-<2-(4-bromobenzoyloxy)ethyl>-1-(4-methoxy-2,3,6-trimethylbenzenesulfonylimino)-3-methyl-1,2,4a,5,6,7-hexahydropyrrolo<1,2-c>pyrimidine-4-carboxylic acid benzyl ester
• CAS No.: 221493-47-6
• Molecular Formula: C₃₅H₃₈BrN₃O₇S
• Molecular Weight: 724.673
• Mol file: 221493-47-6.mol

Synonyms:

Chemical Property of (4aS,7S)-7-<2-(4-bromobenzoyloxy)ethyl>-1-(4-methoxy-2,3,6-trimethylbenzenesulfonylimino)-3-methyl-1,2,4a,5,6,7-hexahydropyrrolo<1,2-c>pyrimidine-4-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4aS,7S)-7-<2-(4-bromobenzoyloxy)ethyl>-1-(4-methoxy-2,3,6-trimethylbenzenesulfonylimino)-3-methyl-1,2,4a,5,6,7-hexahydropyrrolo<1,2-c>pyrimidine-4-carboxylic acid benzyl ester

There total 1 articles about (4aS,7S)-7-<2-(4-bromobenzoyloxy)ethyl>-1-(4-methoxy-2,3,6-trimethylbenzenesulfonylimino)-3-methyl-1,2,4a,5,6,7-hexahydropyrrolo<1,2-c>pyrimidine-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobenzoyl chloride (586-75-4) + (S)-7-(2-Hydroxy-ethyl)-1-[(Z)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-3-methyl-1,2,4a,5,6,7-hexahydro-pyrrolo[1,2-c]pyrimidine-4-carboxylic acid benzyl ester → (4aR,7S)-7-<2-(4-bromobenzoyloxy)ethyl>-1-(4-methoxy-2,3,6-trimethylbenzenesulfonylimino)-3-methyl-1,2,4a,5,6,7-hexahydropyrrolo<1,2-c>pyrimidine-4-carboxylic acid benzyl ester + (4aS,7S)-7-<2-(4-bromobenzoyloxy)ethyl>-1-(4-methoxy-2,3,6-trimethylbenzenesulfonylimino)-3-methyl-1,2,4a,5,6,7-hexahydropyrrolo<1,2-c>pyrimidine-4-carboxylic acid benzyl ester (221493-47-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃; for 1h; Yield given;

DOI:10.1021/jo981972g

Reference yield:

(4aS,7S)-7-<2-(4-bromobenzoyloxy)ethyl>-1-(4-methoxy-2,3,6-trimethylbenzenesulfonylimino)-3-methyl-1,2,4a,5,6,7-hexahydropyrrolo<1,2-c>pyrimidine-4-carboxylic acid benzyl ester (221493-47-6) → (4aS,7S)-1-(4-bromobenzoylimino)-7-<2-(4-bromobenzoyloxy)ethyl>-3-methyl-1,2,4a,5,6,7-hexahydropyrrolo<1,2-c>pyrimidine-4-carboxylic acid benzyl ester hydroformate

Guidance literature:

Multi-step reaction with 2 steps

1: TFA / 1 h / Ambient temperature

2: 4 mg / Et₃N, DMAP / CH₂Cl₂ / 1 h / 0 °C

With dmap; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo981972g

Reference yield:

(4aS,7S)-7-<2-(4-bromobenzoyloxy)ethyl>-1-(4-methoxy-2,3,6-trimethylbenzenesulfonylimino)-3-methyl-1,2,4a,5,6,7-hexahydropyrrolo<1,2-c>pyrimidine-4-carboxylic acid benzyl ester (221493-47-6) → (4aS,7S)-7-[2-(4-Bromo-benzoyloxy)-ethyl]-1-imino-3-methyl-1,2,4a,5,6,7-hexahydro-pyrrolo[1,2-c]pyrimidine-4-carboxylic acid benzyl ester

Guidance literature:

With trifluoroacetic acid; for 1h; Ambient temperature;

DOI:10.1021/jo981972g

upstream raw materials:

4-chlorobenzoyl chloride