4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE

Base Information

• Chemical Name: 4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE
• CAS No.: 13129-17-4
• Molecular Formula: C8H10S
• Molecular Weight: 138.23000
• Hs Code.: 2934999090
• Mol file: 13129-17-4.mol

Synonyms:2-Amino-4,5,6,7-tetrahydro-benzothiazol;4,5,6,7-tetrahydrobenzothiophene;4,5,6,7-tetrahydro-benzo[b]thiophen-2-ylamine;4,5,6,7-tetrahydrobenzothiophen-2-amine;4,5,6,7-Tetrahydrobenzo[b]thiophene;4,5,6,7 tetrahydro thiaindene;4,5,6,7-tetrahydro-benzo[b]thiophene;4,5,6,7-Tetrahydro-benzo[b]thiophen;4,5,6,7-Tetrahydrobenzo[b]thiophen-2-amine;2-Amino-4,5,6,7-tetrahydro-benzothiophen;2-amino-4,5,6,7-tetrahydrobenzothiophene;

Chemical Property of 4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE

Chemical Property:

• Refractive Index: 1.5580
• Boiling Point: 55℃/1mm
• PSA: 28.24000
• Density: 1.099±0.06 g/cm3(Predicted)
• LogP: 2.62690
• Sensitive.: Air Sensitive

Purity/Quality:

99% ^*data from raw suppliers

4,5,6,7-Tetrahydrobenzo[b]thiophene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is an active pharmaceutical intermediate. Condensation of amino carboxyalkyl derivative of 4,5,6,7-tetrahydrobenzo[b]thiophene with salicylaldehyde yielded a potentially tridentate Schiff base (HSAT), which formed a series of copper(II) complexes. Reaction of ethyl 2-diazo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1 with 3-iminobutyronitrile 2 gave the hydrazone derivative.

Technology Process of 4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE

There total 14 articles about 4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-keto-4,5,6,7-tetrahydrothianaphthene (13414-95-4) → 4,5,6,7-tetrahydrobenzo[b]thiophene (13129-17-4)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In diethylene glycol; at 180 ℃; for 8h;

DOI:10.1016/S0223-5234(99)80011-7

Reference yield: 82.0%

1-[(ethoxycarbonothioyl)thio]-2-(2-oxocyclohexyl)ethyl pivalate (1509927-87-0) → 4,5,6,7-tetrahydrobenzo[b]thiophene (13129-17-4)

Guidance literature:

With acetic acid; potassium iodide; at 110 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.1021/ol403310f

Reference yield: 51.0%

3-<ω-(4-Methoxyphenoxy)butyl>thiophene (125878-84-4) → 4,5,6,7-tetrahydrobenzo[b]thiophene (13129-17-4) + 3-(4-bromobutyl)thiophene (125878-89-9)

Guidance literature:

With hydrogen bromide; acetic anhydride; at 100 ℃;

upstream raw materials:

4-keto-4,5,6,7-tetrahydrothianaphthene

(2-oxocyclohexyl)acetic acid

3-<ω-(4-Methoxyphenoxy)butyl>thiophene

2-thiophenebutyric acid

Downstream raw materials:

2-(2-methylbenzoyl)-4,5,6,7-tetrahydrobenzothiophene

4,5,6,7-Tetrahydro-benzo[b]thiophene-2-sulfonyl chloride

2-(2-methylbenzoyl)benzothiophene

2-(o-methylbenzyl)benzothiophene

Refernces

• 1、 -. "ARYLAMIDES AND METHODS OF USE THEREOF". Page/Page column 74-75; 81-82. . Retrieved 2021/06/11.
• 2、 Cal, Dariusz. "A new access to 2-phosphonothiophenes". . p. 1332 - 1335. Retrieved 2014/03/21.