CALPAIN INHIBITOR IV

Base Information

• Chemical Name: CALPAIN INHIBITOR IV
• CAS No.: 133410-84-1
• Molecular Formula: C₃₀H₄₀FN₃O₆
• Molecular Weight: 557.663
• Mol file: 133410-84-1.mol

Synonyms:

Chemical Property of CALPAIN INHIBITOR IV

Chemical Property:

• Boiling Point: 800.9±65.0 °C(Predicted)
• PKA: 9.81±0.15(Predicted)
• Density: 1.176±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Calpain Inhibitor IV is used in the inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV).

Technology Process of CALPAIN INHIBITOR IV

There total 2 articles about CALPAIN INHIBITOR IV which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

<(benzyloxycarbonyl)leucylleucyl-D,L-O-(fluoroacetyl)tyrosyl>fluoromethane (137362-98-2,137490-23-4) → <(benzyloxycarbonyl)leucylleucyl-D,L-tyrosyl>fluoromethane (1250266-70-6,133410-84-1)

Guidance literature:

With hydrogenchloride; In methanol; for 48h; Ambient temperature;

DOI:10.1021/jm00080a003

Reference yield:

(benzyloxycarbonyl)leucylleucyltyrosine (137363-00-9) → <(benzyloxycarbonyl)leucylleucyl-D,L-tyrosyl>fluoromethane (1250266-70-6,133410-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 6.3 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / Ambient temperature

2: 46 percent / 1 N aq. HCl / methanol / 48 h / Ambient temperature

With hydrogenchloride; dmap; triethylamine; In methanol; dichloromethane;

DOI:10.1021/jm00080a003

upstream raw materials:

<(benzyloxycarbonyl)leucylleucyl-D,L-O-(fluoroacetyl)tyrosyl>fluoromethane

(benzyloxycarbonyl)leucylleucyltyrosine

Refernces