Z-Lly-fmk

Base Information

Chemical Name:Z-Lly-fmk
CAS No.:133410-84-1
Molecular Formula:C₃₀H₄₀FN₃O₆
Molecular Weight:557.663
Hs Code.:
DSSTox Substance ID:DTXSID90587890
Mol file:133410-84-1.mol

Synonyms:benzyloxycarbonyl-leucyl-glucyl-tyrosine fluoromethyl ketone;Z-Leu-Leu-Tyr-fluoromethyl ketone;Z-LLY-FMK

Suppliers and Price of Z-Lly-fmk

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 18 raw suppliers

Chemical Property of Z-Lly-fmk

Chemical Property:

Boiling Point:800.9±65.0 °C(Predicted)
PKA:9.81±0.15(Predicted)
Density:1.176±0.06 g/cm3(Predicted)
Storage Temp.:-20°C
XLogP3:5.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:16
Exact Mass:557.29011417
Heavy Atom Count:40
Complexity:809

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)CF)NC(=O)C(CC(C)C)NC(=O)OCC2=CC=CC=C2
Uses Calpain Inhibitor IV is used in the inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV).

Technology Process of Z-Lly-fmk

There total 2 articles about Z-Lly-fmk which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 137362-98-2,137490-23-4
<(benzyloxycarbonyl)leucylleucyl-D,L-O-(fluoroacetyl)tyrosyl>fluoromethane

: 1250266-70-6,133410-84-1
<(benzyloxycarbonyl)leucylleucyl-D,L-tyrosyl>fluoromethane

Guidance literature:: With hydrogenchloride; In methanol; for 48h; Ambient temperature;
DOI:10.1021/jm00080a003

Reference yield:

: 137363-00-9
(benzyloxycarbonyl)leucylleucyltyrosine

: 1250266-70-6,133410-84-1
<(benzyloxycarbonyl)leucylleucyl-D,L-tyrosyl>fluoromethane

Guidance literature:: Multi-step reaction with 2 steps

1: 6.3 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / Ambient temperature

2: 46 percent / 1 N aq. HCl / methanol / 48 h / Ambient temperature

With hydrogenchloride; dmap; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00080a003