(3S,4S)-3,4-epoxy-2,2-dimethylchromane

Base Information

• Chemical Name: (3S,4S)-3,4-epoxy-2,2-dimethylchromane
• CAS No.: 135682-95-0
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.215
• Mol file: 135682-95-0.mol

Synonyms:

Chemical Property of (3S,4S)-3,4-epoxy-2,2-dimethylchromane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4S)-3,4-epoxy-2,2-dimethylchromane

There total 23 articles about (3S,4S)-3,4-epoxy-2,2-dimethylchromane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,2-dimethyl-2H-chromene (2513-25-9) → (3R,4R)-3,4-epoxy-2,2-dimethylchromane (58740-82-2,87894-83-5,135682-95-0,135682-97-2)

Guidance literature:

With sodium hypochlorite; substituted Mn(III)(salen); In dichloromethane; at 0 ℃; for 8h;

DOI:10.1016/j.tetasy.2005.09.022

Reference yield: 97.0%

(1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (3R,4S)-3-bromo-2,2-dimethyl-chroman-4-yl ester (180469-88-9) → (3S,4S)-3,4-epoxy-2,2-dimethylchromane (58740-82-2,87894-83-5,135682-95-0,135682-97-2)

Guidance literature:

With sodium methylate; In tetrahydrofuran; diethyl ether; for 2h; Ambient temperature;

DOI:10.1039/p19960001757

Reference yield: 97.0%

(1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (3S,4R)-3-bromo-2,2-dimethyl-chroman-4-yl ester (180303-21-3) → (3R,4R)-3,4-epoxy-2,2-dimethylchromane (58740-82-2,87894-83-5,135682-95-0,135682-97-2)

Guidance literature:

With sodium methylate; In tetrahydrofuran; diethyl ether; for 2h; Ambient temperature;

DOI:10.1039/p19960001757

upstream raw materials:

2,2-dimethyl-2H-chromene

(1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (3S,4R)-3-bromo-2,2-dimethyl-chroman-4-yl ester

2,3-dihydro-2,2-dimethylbenzo[b]pyran-4-one

3,4-dihydro-4-hydroxy-2,2-dimethyl-2H-benzo[b]pyran