(R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid tert-butyl ester

Base Information

Chemical Name:(R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid tert-butyl ester
CAS No.:343251-08-1
Molecular Formula:C₃₁H₅₂N₂O₄
Molecular Weight:516.765
Hs Code.:

Synonyms:

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Chemical Property of (R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid tert-butyl ester

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Technology Process of (R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid tert-butyl ester

There total 1 articles about (R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 195823-89-3
R-2-nonyl-succinic acid 4-t-butyl ester

: (S)-2-Amino-3,3-dimethyl-N-((R)-1-phenyl-ethyl)-butyramide

: 343251-08-1
(R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; for 18h;
DOI:10.1016/S0960-894X(00)00720-4

Reference yield:

: 343251-08-1
(R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid tert-butyl ester

: 343251-11-6
(R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid

Guidance literature:: With hydrogenchloride; In dichloromethane; at 0 ℃;
DOI:10.1016/S0960-894X(00)00720-4

Reference yield:

: 343251-08-1
(R)-3-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-dodecanoic acid tert-butyl ester

: N¹-[2,2-dimethyl-1-(1-phenyl-ethylcarbamoyl)-propyl]-N⁴-hydroxy-2-nonyl-succinamide

Guidance literature:: Multi-step reaction with 3 steps

1: HCl gas / CH₂Cl₂ / 0 °C

2: N-ethyl-N'-dimethylaminopropylcarbodiimide; 7-aza-1-hydroxy-1,2,3-benzotriazole; Et₃N / CH₂Cl₂ / 18 h

3: ammonium formate / Pd(OAc)2*2PPh₃ / ethanol; H₂O / 2 h / Heating

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; ammonium formate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; bis(triphenylphosphine) palladium (Il) acetate; In ethanol; dichloromethane; water;
DOI:10.1016/S0960-894X(00)00720-4