(1aR,4R,4aR,7S,7aS,7bR)-7-[(R)-1-(3,5-Bis-hydroxymethyl-2,4,6-trimethoxy-phenyl)-3-methyl-butyl]-1,1,4,7-tetramethyl-decahydro-cyclopropa[e]azulen-4-ol

Base Information

Chemical Name:(1aR,4R,4aR,7S,7aS,7bR)-7-[(R)-1-(3,5-Bis-hydroxymethyl-2,4,6-trimethoxy-phenyl)-3-methyl-butyl]-1,1,4,7-tetramethyl-decahydro-cyclopropa[e]azulen-4-ol
CAS No.:142628-51-1
Molecular Formula:C₃₁H₅₀O₆
Molecular Weight:518.734
Hs Code.:

(1aR,4R,4aR,7S,7aS,7bR)-7-[(R)-1-(3,5-Bis-hydroxymethyl-2,4,6-trimethoxy-phenyl)-3-methyl-butyl]-1,1,4,7-tetramethyl-decahydro-cyclopropa[e]azulen-4-ol

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Chemical Property of (1aR,4R,4aR,7S,7aS,7bR)-7-[(R)-1-(3,5-Bis-hydroxymethyl-2,4,6-trimethoxy-phenyl)-3-methyl-butyl]-1,1,4,7-tetramethyl-decahydro-cyclopropa[e]azulen-4-ol

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Technology Process of (1aR,4R,4aR,7S,7aS,7bR)-7-[(R)-1-(3,5-Bis-hydroxymethyl-2,4,6-trimethoxy-phenyl)-3-methyl-butyl]-1,1,4,7-tetramethyl-decahydro-cyclopropa[e]azulen-4-ol

There total 5 articles about (1aR,4R,4aR,7S,7aS,7bR)-7-[(R)-1-(3,5-Bis-hydroxymethyl-2,4,6-trimethoxy-phenyl)-3-methyl-butyl]-1,1,4,7-tetramethyl-decahydro-cyclopropa[e]azulen-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 142628-50-0
C₃₅H₅₂O₈

: 142628-51-1
(1aR,4R,4aR,7S,7aS,7bR)-7-[(R)-1-(3,5-Bis-hydroxymethyl-2,4,6-trimethoxy-phenyl)-3-methyl-butyl]-1,1,4,7-tetramethyl-decahydro-cyclopropa[e]azulen-4-ol

Guidance literature:: With sodium triethylborohydride;
DOI:10.1016/S0040-4039(00)79578-5

Reference yield:

: 142628-53-3
2,4,6-trihydroxy-5-((R)-3-methyl-1-((1aR,4aR,7S,7aR,7bR)-1,1,7-trimethyl-4-methylenedecahydro-1Hcyclopropa[e]azulen-7-yl)butyl)isophthalaldehyde

: 142628-51-1
(1aR,4R,4aR,7S,7aS,7bR)-7-[(R)-1-(3,5-Bis-hydroxymethyl-2,4,6-trimethoxy-phenyl)-3-methyl-butyl]-1,1,4,7-tetramethyl-decahydro-cyclopropa[e]azulen-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / acetonitrile

2: NaBH₄ / ethanol

3: pyridine

4: 39 percent / m-COBA / 0 °C

5: 54 percent / NaBHEt₃

With pyridine; sodium tetrahydroborate; sodium triethylborohydride; potassium carbonate; In ethanol; acetonitrile;
DOI:10.1016/S0040-4039(00)79578-5

Reference yield:

: 201207-55-8
(+)-5-<(1'R)-1'-((1R,2R,4R,8R,11S)-3,3,11-trimethyl-7-methylenetricyclo<6.3.0.0^2,4>undec-11-yl)-3'-methylbutyl>-2,4,6-trimethoxyisophthalaldehyde

: 142628-51-1
(1aR,4R,4aR,7S,7aS,7bR)-7-[(R)-1-(3,5-Bis-hydroxymethyl-2,4,6-trimethoxy-phenyl)-3-methyl-butyl]-1,1,4,7-tetramethyl-decahydro-cyclopropa[e]azulen-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / ethanol

2: pyridine

3: 39 percent / m-COBA / 0 °C

4: 54 percent / NaBHEt₃

With pyridine; sodium tetrahydroborate; sodium triethylborohydride; In ethanol;
DOI:10.1016/S0040-4039(00)79578-5