Technology Process of (2R,3S,4R,E)-2,3,4-tris(benzyloxy)-7-methyl-N-((S)-2-oxoazepan-3-yl)oct-5-enamide
There total 2 articles about (2R,3S,4R,E)-2,3,4-tris(benzyloxy)-7-methyl-N-((S)-2-oxoazepan-3-yl)oct-5-enamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 3 steps
1.1: sodium chlorite; sodium dihydrogen phosphate monohydrate; dihydrogen peroxide / acetonitrile; water; tert-butyl alcohol / 3 h / 20 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
2.2: 12 h / 20 °C
3.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 24 h / Reflux
With
sodium chlorite; Hoveyda-Grubbs catalyst second generation; sodium dihydrogen phosphate monohydrate; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tet.2012.11.004
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 12 h / 20 °C
2.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 24 h / Reflux
With
Hoveyda-Grubbs catalyst second generation; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.11.004