Technology Process of C25H21Cl2N3
There total 7 articles about C25H21Cl2N3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
toluene;
at 100 ℃;
DOI:10.1016/j.bmcl.2014.03.062
- Guidance literature:
-
Multi-step reaction with 7 steps
1: bromine; potassium hydroxide
2: isobutyl chloroformate; 4-methyl-morpholine / dichloromethane
3: tetrachloromethane / acetonitrile / 50 °C
4: triethylamine / toluene / 100 °C
5: palladium diacetate; tris-(o-tolyl)phosphine; sodium carbonate
6: trifluoroacetic acid
7: tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 100 °C
With
4-methyl-morpholine; tetrachloromethane; tris-(dibenzylideneacetone)dipalladium(0); bromine; palladium diacetate; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; potassium hydroxide; isobutyl chloroformate;
In
dichloromethane; toluene; acetonitrile;
5: |Suzuki Coupling / 7: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2014.03.062
- Guidance literature:
-
Multi-step reaction with 6 steps
1: isobutyl chloroformate; 4-methyl-morpholine / dichloromethane
2: tetrachloromethane / acetonitrile / 50 °C
3: triethylamine / toluene / 100 °C
4: palladium diacetate; tris-(o-tolyl)phosphine; sodium carbonate
5: trifluoroacetic acid
6: tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 100 °C
With
4-methyl-morpholine; tetrachloromethane; tris-(dibenzylideneacetone)dipalladium(0); palladium diacetate; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; isobutyl chloroformate;
In
dichloromethane; toluene; acetonitrile;
4: |Suzuki Coupling / 6: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2014.03.062