tert-butyl (2R)-1-((2R,3R,4S,5R)-5-((((2R,3S,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yloxy)(2-cyanoethoxy)phosphoryloxy)methyl)-2-(6-benzamido-9H-purin-9-yl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-ylamino)-1-oxopropan-2-ylcarbamate

Base Information

• Chemical Name: tert-butyl (2R)-1-((2R,3R,4S,5R)-5-((((2R,3S,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yloxy)(2-cyanoethoxy)phosphoryloxy)methyl)-2-(6-benzamido-9H-purin-9-yl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-ylamino)-1-oxopropan-2-ylcarbamate
• CAS No.: 1452385-23-7
• Molecular Formula: C₄₅H₆₂N₁₁O₁₄PSi
• Molecular Weight: 1040.11

Synonyms:

Chemical Property of tert-butyl (2R)-1-((2R,3R,4S,5R)-5-((((2R,3S,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yloxy)(2-cyanoethoxy)phosphoryloxy)methyl)-2-(6-benzamido-9H-purin-9-yl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-ylamino)-1-oxopropan-2-ylcarbamate

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of tert-butyl (2R)-1-((2R,3R,4S,5R)-5-((((2R,3S,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yloxy)(2-cyanoethoxy)phosphoryloxy)methyl)-2-(6-benzamido-9H-purin-9-yl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-ylamino)-1-oxopropan-2-ylcarbamate

There total 1 articles about tert-butyl (2R)-1-((2R,3R,4S,5R)-5-((((2R,3S,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yloxy)(2-cyanoethoxy)phosphoryloxy)methyl)-2-(6-benzamido-9H-purin-9-yl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-ylamino)-1-oxopropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C66H80N11O16PSi → tert-butyl (2R)-1-((2R,3R,4S,5R)-5-((((2R,3S,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yloxy)(2-cyanoethoxy)phosphoryloxy)methyl)-2-(6-benzamido-9H-purin-9-yl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-ylamino)-1-oxopropan-2-ylcarbamate (1452385-23-7)

Guidance literature:

With trichloroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1039/c3ob41206g

Reference yield:

tert-butyl (2R)-1-((2R,3R,4S,5R)-5-((((2R,3S,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yloxy)(2-cyanoethoxy)phosphoryloxy)methyl)-2-(6-benzamido-9H-purin-9-yl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-ylamino)-1-oxopropan-2-ylcarbamate (1452385-23-7) + bis(2-cyanoethyl) diisopropylamidophosphite (102690-88-0) → C54H79N13O15P2Si

Guidance literature:

tert-butyl (2R)-1-((2R,3R,4S,5R)-5-((((2R,3S,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yloxy)(2-cyanoethoxy)phosphoryloxy)methyl)-2-(6-benzamido-9H-purin-9-yl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-ylamino)-1-oxopropan-2-ylcarbamate; bis(2-cyanoethyl) diisopropylamidophosphite; With 1H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃; for 1h;

With pyridine; iodine; In tetrahydrofuran; dichloromethane; water; acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1039/c3ob41206g

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