{(S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-cyclohexyl-2-hydroxy-butyl}-phosphonic acid dibutyl ester

Base Information

Chemical Name:{(S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-cyclohexyl-2-hydroxy-butyl}-phosphonic acid dibutyl ester
CAS No.:123381-42-0
Molecular Formula:C₃₈H₆₂N₅O₈P
Molecular Weight:747.913
Hs Code.:

{(S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-cyclohexyl-2-hydroxy-butyl}-phosphonic acid dibutyl ester

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Chemical Property of {(S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-cyclohexyl-2-hydroxy-butyl}-phosphonic acid dibutyl ester

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Technology Process of {(S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-cyclohexyl-2-hydroxy-butyl}-phosphonic acid dibutyl ester

There total 5 articles about {(S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-cyclohexyl-2-hydroxy-butyl}-phosphonic acid dibutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: ((S)-3-Amino-4-cyclohexyl-2-hydroxy-butyl)-phosphonic acid dibutyl ester; hydrochloride

: 17791-52-5
N-(tert-butoxycarbonyl)-L-histidine

: 123381-42-0,123482-54-2
{(S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-cyclohexyl-2-hydroxy-butyl}-phosphonic acid dibutyl ester

Guidance literature:: Multistep reaction;
DOI:10.1021/jm00164a011

Reference yield:

: 2404-73-1
dibutyl methylphosphonate

: 123381-42-0,123482-54-2
{(S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-cyclohexyl-2-hydroxy-butyl}-phosphonic acid dibutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sec-butyllithium / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) 0.5 h

2: H₂, HCl (gas) / 10percent Pd/C / ethyl acetate; dioxane / 760 Torr / Ambient temperature

With hydrogenchloride; hydrogen; sec.-butyllithium; palladium on activated charcoal; In 1,4-dioxane; ethyl acetate;
DOI:10.1021/jm00164a011

Reference yield:

: 123381-14-6
N-tritylcyclohexylalaninol

: 123381-42-0,123482-54-2
{(S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-cyclohexyl-2-hydroxy-butyl}-phosphonic acid dibutyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride, dimethylsulfoxide, triethylamine / CH₂Cl₂ / 0.5 h / -60 °C

2: 1.) sec-butyllithium / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) 0.5 h

3: H₂, HCl (gas) / 10percent Pd/C / ethyl acetate; dioxane / 760 Torr / Ambient temperature

With hydrogenchloride; oxalyl dichloride; hydrogen; sec.-butyllithium; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1021/jm00164a011