(3S,7S,7aR)-5-<(2R)-2-(3,4-dihydroxyphenyl)-2-<4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino>acetamido>-7-formamido-2,2-dimethyl-2,3,7,7a-tetrahydroimidazo<5,1-b>thiazole-3,7-dicarboxylic acid

Base Information

Chemical Name:(3S,7S,7aR)-5-<(2R)-2-(3,4-dihydroxyphenyl)-2-<4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino>acetamido>-7-formamido-2,2-dimethyl-2,3,7,7a-tetrahydroimidazo<5,1-b>thiazole-3,7-dicarboxylic acid
CAS No.:130194-65-9
Molecular Formula:C₂₄H₂₈N₆O₁₀S
Molecular Weight:592.587
Hs Code.:

(3S,7S,7aR)-5-<(2R)-2-(3,4-dihydroxyphenyl)-2-<4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino>acetamido>-7-formamido-2,2-dimethyl-2,3,7,7a-tetrahydroimidazo<5,1-b>thiazole-3,7-dicarboxylic acid

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Chemical Property of (3S,7S,7aR)-5-<(2R)-2-(3,4-dihydroxyphenyl)-2-<4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino>acetamido>-7-formamido-2,2-dimethyl-2,3,7,7a-tetrahydroimidazo<5,1-b>thiazole-3,7-dicarboxylic acid

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Technology Process of (3S,7S,7aR)-5-<(2R)-2-(3,4-dihydroxyphenyl)-2-<4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino>acetamido>-7-formamido-2,2-dimethyl-2,3,7,7a-tetrahydroimidazo<5,1-b>thiazole-3,7-dicarboxylic acid

There total 6 articles about (3S,7S,7aR)-5-<(2R)-2-(3,4-dihydroxyphenyl)-2-<4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino>acetamido>-7-formamido-2,2-dimethyl-2,3,7,7a-tetrahydroimidazo<5,1-b>thiazole-3,7-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74955-73-0
(2R)-2-(3,4-dihydroxyphenyl)-2-<(4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino>acetic acid

: 130194-65-9
(3S,7S,7aR)-5-<(2R)-2-(3,4-dihydroxyphenyl)-2-<4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino>acetamido>-7-formamido-2,2-dimethyl-2,3,7,7a-tetrahydroimidazo<5,1-b>thiazole-3,7-dicarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / aq. NaHCO₃ / tetrahydrofuran / 0.25 h / 25 - 30 °C / pH 8.0

3: 1) 2M HCl, 2) H₂ / 2) 10percent Pd/C / 1) THF, r.t., 1h, 2) MeOH, r.t.

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran;

Reference yield:

: 130130-35-7
benzyl 6β-<(2R)-2-<3,4-bis(benzyloxycarbonyloxy)phenyl>-2-<(4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino>>-6α-formamidopenicillanate

: 130194-65-9
(3S,7S,7aR)-5-<(2R)-2-(3,4-dihydroxyphenyl)-2-<4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino>acetamido>-7-formamido-2,2-dimethyl-2,3,7,7a-tetrahydroimidazo<5,1-b>thiazole-3,7-dicarboxylic acid

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; Yield given. Multistep reaction; 1) THF, r.t., 1h, 2) MeOH, r.t.;

Reference yield:

: 40514-98-5
benzyl 6β-amino-6α-methylthiopenicillanate

: 130194-65-9
(3S,7S,7aR)-5-<(2R)-2-(3,4-dihydroxyphenyl)-2-<4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino>acetamido>-7-formamido-2,2-dimethyl-2,3,7,7a-tetrahydroimidazo<5,1-b>thiazole-3,7-dicarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

2: 1) 2M HCl, 2) H₂ / 2) 10percent Pd/C / 1) THF, r.t., 1h, 2) MeOH, r.t.

With hydrogenchloride; hydrogen; palladium on activated charcoal;