C₂₁H₃₂N₂O₄S

Base Information

• Chemical Name: C₂₁H₃₂N₂O₄S
• CAS No.: 127232-67-1
• Molecular Formula: C₂₁H₃₂N₂O₄S
• Molecular Weight: 408.562
• Mol file: 127232-67-1.mol

Synonyms:

Chemical Property of C₂₁H₃₂N₂O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₃₂N₂O₄S

There total 6 articles about C₂₁H₃₂N₂O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4aR,5S,8aR)-3,4,4a,5,6,7,8,8a-octahydro-5-<(methoxymethoxy)methyl>-8a-methyl-1(2H)-naphthalenone 1-ethylene acetal (127232-65-9) → C21H32N2O4S (127232-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / p-toluenesulfonic acid monohydrate / acetone; H₂O / 14 h / Ambient temperature

2: ethanol / 4 h / Heating

With toluene-4-sulfonic acid; In ethanol; water; acetone;

DOI:10.1021/jo00297a035

Reference yield:

(4aR,5S,6S,8aR)-3,4,4a,5,6,7,8,8a-octahydro-6-hydroxy-5-<(methoxymethoxy)methyl>-8a-methyl-1(2H)-naphthalenone 1-ethylene acetal (127232-63-7) → C21H32N2O4S (127232-67-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1. butyllithium

2: 92 percent / tributyltin hydride, α,α'-azobisisobutyronitrile / toluene / 0.5 h / 90 °C

3: 98 percent / p-toluenesulfonic acid monohydrate / acetone; H₂O / 14 h / Ambient temperature

4: ethanol / 4 h / Heating

With n-butyllithium; azobisisobutyronitrile; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; In ethanol; water; acetone; toluene;

DOI:10.1021/jo00297a035

Reference yield:

(4aR,5S,8aR)-3,4,4a,5,8,8a-hexahydro-5-(hydroxymethyl)-8a-methyl-1,6-(2H,7H)-naphthalenedione 1-ethylene acetal (117439-20-0) → C21H32N2O4S (127232-67-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 80 percent / N,N-diisopropylethylamine / CH₂Cl₂ / Ambient temperature

2: 1. lithium tri-sec-butylborohydride 2. aqu. NaOH / aqu. H₂O₂ / 1. THF, 0 deg C, 35 min 2. 30 min, room temp.

3: 1. butyllithium

4: 92 percent / tributyltin hydride, α,α'-azobisisobutyronitrile / toluene / 0.5 h / 90 °C

5: 98 percent / p-toluenesulfonic acid monohydrate / acetone; H₂O / 14 h / Ambient temperature

6: ethanol / 4 h / Heating

With sodium hydroxide; n-butyllithium; azobisisobutyronitrile; dihydrogen peroxide; tri-n-butyl-tin hydride; L-Selectride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water; acetone; toluene;

DOI:10.1021/jo00297a035

upstream raw materials:

(4aR,5S,8aR)-3,4,4a,5,6,7,8,8a-octahydro-5-<(methoxymethoxy)methyl>-8a-methyl-1(2H)-naphthalenone

toluene-4-sulfonic acid hydrazide

(4aR,5S,8aR)-3,4,4a,5,6,7,8,8a-octahydro-5-<(methoxymethoxy)methyl>-8a-methyl-1(2H)-naphthalenone 1-ethylene acetal

(4aR,5S,6S,8aR)-3,4,4a,5,6,7,8,8a-octahydro-6-hydroxy-5-<(methoxymethoxy)methyl>-8a-methyl-1(2H)-naphthalenone 1-ethylene acetal

Downstream raw materials:

Xestoquinone