(3S,4S)-5-Cyclohexyl-4-{2-ethoxy-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-acetylamino}-3-hydroxy-pentanoic acid (2-morpholin-4-yl-ethyl)-amide

Base Information

Chemical Name:(3S,4S)-5-Cyclohexyl-4-{2-ethoxy-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-acetylamino}-3-hydroxy-pentanoic acid (2-morpholin-4-yl-ethyl)-amide
CAS No.:125208-73-3
Molecular Formula:C₃₄H₅₆N₆O₉S
Molecular Weight:724.919
Hs Code.:

(3S,4S)-5-Cyclohexyl-4-{2-ethoxy-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-acetylamino}-3-hydroxy-pentanoic acid (2-morpholin-4-yl-ethyl)-amide

Synonyms:

Suppliers and Price of (3S,4S)-5-Cyclohexyl-4-{2-ethoxy-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-acetylamino}-3-hydroxy-pentanoic acid (2-morpholin-4-yl-ethyl)-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4S)-5-Cyclohexyl-4-{2-ethoxy-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-acetylamino}-3-hydroxy-pentanoic acid (2-morpholin-4-yl-ethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4S)-5-Cyclohexyl-4-{2-ethoxy-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-acetylamino}-3-hydroxy-pentanoic acid (2-morpholin-4-yl-ethyl)-amide

There total 5 articles about (3S,4S)-5-Cyclohexyl-4-{2-ethoxy-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-acetylamino}-3-hydroxy-pentanoic acid (2-morpholin-4-yl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 125208-73-3,125278-21-9,139163-24-9
(3S,4S)-5-Cyclohexyl-4-{2-ethoxy-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-acetylamino}-3-hydroxy-pentanoic acid (2-morpholin-4-yl-ethyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 43 percent / 3.33 N aq. NaOH / tetrahydrofuran / 6 h / Ambient temperature

2: 1.) 1,1'-carbonyldiimidazole, 2.) NH₃ gas / 1.) CH₂Cl₂, THF, 45 min, 2.) CH₂Cl₂, THF, RT, overnight

3: 72.3 percent / acetone / 48 h / Heating

4: 66 percent / conc. aq. H₂SO₄ / 5 h / Ambient temperature

5: 97.9 percent / 1 N aq. NaOH / ethanol / 1 h / Ambient temperature

6: HOBt, DCC / dimethylformamide

With sodium hydroxide; sulfuric acid; ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00084a008

Reference yield:

: 124278-39-3
N-(4-MorpholinYlsulfonyl)-L-phenylalanine

: 125208-73-3,125278-21-9,139163-24-9
(3S,4S)-5-Cyclohexyl-4-{2-ethoxy-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-acetylamino}-3-hydroxy-pentanoic acid (2-morpholin-4-yl-ethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 1,1'-carbonyldiimidazole, 2.) NH₃ gas / 1.) CH₂Cl₂, THF, 45 min, 2.) CH₂Cl₂, THF, RT, overnight

2: 72.3 percent / acetone / 48 h / Heating

3: 66 percent / conc. aq. H₂SO₄ / 5 h / Ambient temperature

4: 97.9 percent / 1 N aq. NaOH / ethanol / 1 h / Ambient temperature

5: HOBt, DCC / dimethylformamide

With sodium hydroxide; sulfuric acid; ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00084a008

Reference yield:

: 125191-22-2
N-(4-morpholinylsilfonyl)-L-phenylalaninamide

: 125208-73-3,125278-21-9,139163-24-9
(3S,4S)-5-Cyclohexyl-4-{2-ethoxy-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-acetylamino}-3-hydroxy-pentanoic acid (2-morpholin-4-yl-ethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 72.3 percent / acetone / 48 h / Heating

2: 66 percent / conc. aq. H₂SO₄ / 5 h / Ambient temperature

3: 97.9 percent / 1 N aq. NaOH / ethanol / 1 h / Ambient temperature

4: HOBt, DCC / dimethylformamide

With sodium hydroxide; sulfuric acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00084a008