(+)-8-phenylisomenthyl bromoacetate

Base Information

• Chemical Name: (+)-8-phenylisomenthyl bromoacetate
• CAS No.: 129180-90-1
• Molecular Formula: C₁₈H₂₅BrO₂
• Molecular Weight: 353.299
• Mol file: 129180-90-1.mol

Synonyms:

Chemical Property of (+)-8-phenylisomenthyl bromoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-8-phenylisomenthyl bromoacetate

There total 3 articles about (+)-8-phenylisomenthyl bromoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(1S,2R,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexanol (100101-42-6) + bromoacetic acid (79-08-3) → 1-(1-methyl-1-phenylethyl)-4-methylcyclohexene (129180-91-2) + (+)-8-phenylisomenthyl bromoacetate (129180-90-1)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 13.5h; Heating;

Reference yield:

(5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexanol (57707-91-2,65253-04-5,99528-57-1,100101-42-6,104870-75-9,104870-80-6,122517-58-2,134256-18-1) → (+)-8-phenylisomenthyl bromoacetate (129180-90-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 12.9 g / 4-dimethylaminopyridine / benzene / 23 h / 70 - 75 °C

2: 97 percent / sodium ethoxide / ethanol / 15 h / Heating

3: 80 percent / p-toluenesulfonic acid / benzene / 13.5 h / Heating

With dmap; sodium ethanolate; toluene-4-sulfonic acid; In ethanol; benzene;

Reference yield:

Phenyl-carbamic acid (1S,2R,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester (129180-87-6,129180-88-7,129180-89-8) → (+)-8-phenylisomenthyl bromoacetate (129180-90-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / sodium ethoxide / ethanol / 15 h / Heating

2: 80 percent / p-toluenesulfonic acid / benzene / 13.5 h / Heating

With sodium ethanolate; toluene-4-sulfonic acid; In ethanol; benzene;

upstream raw materials:

(1S,2R,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexanol

bromoacetic acid

(5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexanol

Phenyl-carbamic acid (1S,2R,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Downstream raw materials:

(1S,2R,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl glyoxylate

Nitrooxy-acetic acid (1S,2R,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Refernces