4-((3S,5R,8R,9S,10S,13R,14S,15R,17S)-3-Benzyloxy-15-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one

Base Information

• Chemical Name: 4-((3S,5R,8R,9S,10S,13R,14S,15R,17S)-3-Benzyloxy-15-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one
• CAS No.: 73336-62-6
• Molecular Formula: C₃₀H₄₀O₄
• Molecular Weight: 464.645
• Mol file: 73336-62-6.mol

Synonyms:

Chemical Property of 4-((3S,5R,8R,9S,10S,13R,14S,15R,17S)-3-Benzyloxy-15-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((3S,5R,8R,9S,10S,13R,14S,15R,17S)-3-Benzyloxy-15-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one

There total 4 articles about 4-((3S,5R,8R,9S,10S,13R,14S,15R,17S)-3-Benzyloxy-15-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-((3S,5R,8R,9S,10S,13S,14S,15R)-3-Benzyloxy-15-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one (78799-94-7) → 4-((3S,5R,8R,9S,10S,13R,14S,15R,17S)-3-Benzyloxy-15-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one (73336-62-6)

Guidance literature:

With hydrogen; Lindlar's catalyst; In ethanol; Yield given;

DOI:10.1139/v81-206

Reference yield:

(3S,5R,8R,9S,10S,13S,14S,15R)-3-Benzyloxy-17-(5-methoxy-furan-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-15-ol (78799-93-6) → 4-((3S,5R,8R,9S,10S,13R,14S,15R,17S)-3-Benzyloxy-15-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one (73336-62-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dil. HCl / H₂O; tetrahydrofuran / 5 h / Ambient temperature

2: H₂ / Pd/CaCO₃ / ethanol

With hydrogenchloride; hydrogen; Lindlar's catalyst; In tetrahydrofuran; ethanol; water;

DOI:10.1139/v81-206

Reference yield:

(3S,5R,8R,9S,10S,13S,14S,17S)-3-Benzyloxy-17-(5-methoxy-furan-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol (83457-03-8) → 4-((3S,5R,8R,9S,10S,13R,14S,15R,17S)-3-Benzyloxy-15-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one (73336-62-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) acetic anhydride, pyridine; 2.) CaCO₃ / 1.) p-dimethylaminopyridine / 1.) 48 h, RT; 2.) aq. acetone, reflux, 48 h

2: dil. HCl / H₂O; tetrahydrofuran / 5 h / Ambient temperature

3: H₂ / Pd/CaCO₃ / ethanol

With pyridine; hydrogenchloride; hydrogen; acetic anhydride; calcium carbonate; dmap; Lindlar's catalyst; In tetrahydrofuran; ethanol; water;

DOI:10.1139/v81-206

upstream raw materials:

4-((3S,5R,8R,9S,10S,13S,14S,15R)-3-Benzyloxy-15-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one

(3S,5R,8R,9S,10S,13S,14S,15R)-3-Benzyloxy-17-(5-methoxy-furan-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-15-ol

(3S,5R,8R,9S,10S,13S,14S,17S)-3-Benzyloxy-17-(5-methoxy-furan-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol