lithium (3R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylate

Base Information

Chemical Name:lithium (3R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylate
CAS No.:1438852-74-4
Molecular Formula:C₁₀H₁₅FNO₄*Li
Molecular Weight:239.173
Hs Code.:

Synonyms:

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Chemical Property of lithium (3R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylate

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Technology Process of lithium (3R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylate

There total 5 articles about lithium (3R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1438852-72-2
(3R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid

: 1438852-74-4
lithium (3R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylate

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 45 ℃; for 18h;

Reference yield:

: 1279669-60-1
methyl 1-benzyl-3-fluoropyrrolidine-3-carboxylate

: 1438852-74-4
lithium (3R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: Chiralpak IC column / carbon dioxide; propan-1-ol / Resolution of racemate; liquid CO₂

2: palladium 10% on activated carbon; hydrogen / methanol / 22 h / 2327.23 Torr

3: sodium hydroxide; water / methanol / 3.5 h / 20 °C

4: lithium hydroxide / methanol; tetrahydrofuran; water / 18 h / 45 °C

With palladium 10% on activated carbon; water; hydrogen; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; propan-1-ol; carbon dioxide; water;

Reference yield:

: 1438852-68-6
methyl (3R)-1-benzyl-3-fluoropyrrolidine-3-carboxylate

: 1438852-74-4
lithium (3R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 22 h / 2327.23 Torr

2: sodium hydroxide; water / methanol / 3.5 h / 20 °C

3: lithium hydroxide / methanol; tetrahydrofuran; water / 18 h / 45 °C

With palladium 10% on activated carbon; water; hydrogen; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; water;