(2R,3R,4R,5R,6S,7R,8R)-5,7,9-Tris-benzyloxy-2-[1,3]dithian-2-yl-4,6,8-trimethyl-nonan-3-ol

Base Information

Chemical Name:(2R,3R,4R,5R,6S,7R,8R)-5,7,9-Tris-benzyloxy-2-[1,3]dithian-2-yl-4,6,8-trimethyl-nonan-3-ol
CAS No.:123363-74-6
Molecular Formula:C₃₇H₅₀O₄S₂
Molecular Weight:622.934
Hs Code.:

Synonyms:

Suppliers and Price of (2R,3R,4R,5R,6S,7R,8R)-5,7,9-Tris-benzyloxy-2-[1,3]dithian-2-yl-4,6,8-trimethyl-nonan-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R,4R,5R,6S,7R,8R)-5,7,9-Tris-benzyloxy-2-[1,3]dithian-2-yl-4,6,8-trimethyl-nonan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,4R,5R,6S,7R,8R)-5,7,9-Tris-benzyloxy-2-[1,3]dithian-2-yl-4,6,8-trimethyl-nonan-3-ol

There total 14 articles about (2R,3R,4R,5R,6S,7R,8R)-5,7,9-Tris-benzyloxy-2-[1,3]dithian-2-yl-4,6,8-trimethyl-nonan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (Z)-(3R,4R)-3-Hydroxy-4-methyl-hept-5-enal

: 123363-74-6
(2R,3R,4R,5R,6S,7R,8R)-5,7,9-Tris-benzyloxy-2-[1,3]dithian-2-yl-4,6,8-trimethyl-nonan-3-ol

Guidance literature:: Multi-step reaction with 13 steps

1: NaClO₂, 2-methyl-2-butene, NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / from -5 deg C to RT

2: diethyl ether / Ambient temperature

3: LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -50 - -20 °C

4: LAH / tetrahydrofuran / 0 °C

5: 60 percent / VO(acac)2, TBHP / CH₂Cl₂ / from -20 deg C to RT

6: NaH / tetrahydrofuran; dimethylformamide / 50 °C

7: BF₃*OEt₂ / tetrahydrofuran / from -78 deg C to -20 deg C

8: H₂, quinoline / Pd-CaCO₃ / benzene / Ambient temperature

9: 2,6-dimethylpyridine / CH₂Cl₂ / Ambient temperature

10: 67 percent / WO₅*HMPA / CH₂Cl₂ / Ambient temperature

11: n-Bu₄NF / tetrahydrofuran / Ambient temperature

12: NaH / tetrahydrofuran; dimethylformamide / 50 °C

13: tetrahydrofuran / 0 °C

With 2,6-dimethylpyridine; quinoline; tert.-butylhydroperoxide; sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; bis(acetylacetonate)oxovanadium; WO₅*HMPA; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; lithium diisopropyl amide; Lindlar's catalyst; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
DOI:10.1246/cl.1989.117

Reference yield:

: 123363-70-2,123410-28-6
(2R,3R,4S)-2-Methyl-4-((2S,3R)-3-methyl-oxiranyl)-pentane-1,3-diol

: 123363-74-6
(2R,3R,4R,5R,6S,7R,8R)-5,7,9-Tris-benzyloxy-2-[1,3]dithian-2-yl-4,6,8-trimethyl-nonan-3-ol

Guidance literature:: Multi-step reaction with 8 steps

1: NaH / tetrahydrofuran; dimethylformamide / 50 °C

2: BF₃*OEt₂ / tetrahydrofuran / from -78 deg C to -20 deg C

3: H₂, quinoline / Pd-CaCO₃ / benzene / Ambient temperature

4: 2,6-dimethylpyridine / CH₂Cl₂ / Ambient temperature

5: 67 percent / WO₅*HMPA / CH₂Cl₂ / Ambient temperature

6: n-Bu₄NF / tetrahydrofuran / Ambient temperature

7: NaH / tetrahydrofuran; dimethylformamide / 50 °C

8: tetrahydrofuran / 0 °C

With 2,6-dimethylpyridine; quinoline; WO₅*HMPA; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; Lindlar's catalyst; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1246/cl.1989.117

Reference yield:

: 123363-69-9
(Z)-(2R,3S,4R)-2,4-Dimethyl-hept-5-ene-1,3-diol

: 123363-74-6
(2R,3R,4R,5R,6S,7R,8R)-5,7,9-Tris-benzyloxy-2-[1,3]dithian-2-yl-4,6,8-trimethyl-nonan-3-ol

Guidance literature:: Multi-step reaction with 9 steps

1: 60 percent / VO(acac)2, TBHP / CH₂Cl₂ / from -20 deg C to RT

2: NaH / tetrahydrofuran; dimethylformamide / 50 °C

3: BF₃*OEt₂ / tetrahydrofuran / from -78 deg C to -20 deg C

4: H₂, quinoline / Pd-CaCO₃ / benzene / Ambient temperature

5: 2,6-dimethylpyridine / CH₂Cl₂ / Ambient temperature

6: 67 percent / WO₅*HMPA / CH₂Cl₂ / Ambient temperature

7: n-Bu₄NF / tetrahydrofuran / Ambient temperature

8: NaH / tetrahydrofuran; dimethylformamide / 50 °C

9: tetrahydrofuran / 0 °C

With 2,6-dimethylpyridine; quinoline; tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; WO₅*HMPA; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; Lindlar's catalyst; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1246/cl.1989.117