Technology Process of Benzoic acid (2S,5S,6S,7S)-7-acetoxymethyl-7-hydroxy-2,3,3-trimethyl-4-oxo-1-oxa-spiro[4.4]non-6-yl ester
There total 11 articles about Benzoic acid (2S,5S,6S,7S)-7-acetoxymethyl-7-hydroxy-2,3,3-trimethyl-4-oxo-1-oxa-spiro[4.4]non-6-yl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 83 percent
2: CuCl2, H2O
3: 1.) MsCl, R3N, 2.)LiCl
4: 90 percent / NaH
5: 95 percent / m-CPBA
6: 54 percent / Lithium 2,2,6,6-tetramethylpiperidine / diethyl ether; hexamethylphosphoric acid triamide
7: (-)-diethyl-tartarate, Ti3)2>4, (CH3)3COH
8: pyridine
9: H2O, HOAc / Heating
With
titanium(IV) isopropylate; 2,2,6,6-tetramethylpiperidinyl-lithium; water; sodium hydride; acetic acid; methanesulfonyl chloride; (-)-diethyl tartrate; 3-chloro-benzenecarboperoxoic acid; lithium chloride; copper dichloride; tert-butyl alcohol;
In
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
DOI:10.1016/S0040-4039(00)87093-8
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 83 percent
2: CuCl2, H2O
3: 1.) MsCl, R3N, 2.)LiCl
4: 90 percent / NaH
5: 95 percent / m-CPBA
6: 54 percent / Lithium 2,2,6,6-tetramethylpiperidine / diethyl ether; hexamethylphosphoric acid triamide
7: (-)-diethyl-tartarate, Ti3)2>4, (CH3)3COH
8: pyridine
9: H2O, HOAc / Heating
With
titanium(IV) isopropylate; 2,2,6,6-tetramethylpiperidinyl-lithium; water; sodium hydride; acetic acid; methanesulfonyl chloride; (-)-diethyl tartrate; 3-chloro-benzenecarboperoxoic acid; lithium chloride; copper dichloride; tert-butyl alcohol;
In
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
DOI:10.1016/S0040-4039(00)87093-8
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 95 percent / m-CPBA
2: 54 percent / Lithium 2,2,6,6-tetramethylpiperidine / diethyl ether; hexamethylphosphoric acid triamide
3: (-)-diethyl-tartarate, Ti3)2>4, (CH3)3COH
4: pyridine
5: H2O, HOAc / Heating
With
titanium(IV) isopropylate; 2,2,6,6-tetramethylpiperidinyl-lithium; water; acetic acid; (-)-diethyl tartrate; 3-chloro-benzenecarboperoxoic acid; tert-butyl alcohol;
In
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
DOI:10.1016/S0040-4039(00)87093-8
