[(2S,5S)-2-(Benzylcarbamoyl-methyl)-4-tert-butoxycarbonylmethyl-5-methoxycarbonylmethyl-3,6-dioxo-piperazin-1-yl]-acetic acid tert-butyl ester

Base Information

Chemical Name:[(2S,5S)-2-(Benzylcarbamoyl-methyl)-4-tert-butoxycarbonylmethyl-5-methoxycarbonylmethyl-3,6-dioxo-piperazin-1-yl]-acetic acid tert-butyl ester
CAS No.:193287-77-3
Molecular Formula:C₂₈H₃₉N₃O₉
Molecular Weight:561.632
Hs Code.:

[(2S,5S)-2-(Benzylcarbamoyl-methyl)-4-tert-butoxycarbonylmethyl-5-methoxycarbonylmethyl-3,6-dioxo-piperazin-1-yl]-acetic acid tert-butyl ester

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Chemical Property of [(2S,5S)-2-(Benzylcarbamoyl-methyl)-4-tert-butoxycarbonylmethyl-5-methoxycarbonylmethyl-3,6-dioxo-piperazin-1-yl]-acetic acid tert-butyl ester

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Technology Process of [(2S,5S)-2-(Benzylcarbamoyl-methyl)-4-tert-butoxycarbonylmethyl-5-methoxycarbonylmethyl-3,6-dioxo-piperazin-1-yl]-acetic acid tert-butyl ester

There total 6 articles about [(2S,5S)-2-(Benzylcarbamoyl-methyl)-4-tert-butoxycarbonylmethyl-5-methoxycarbonylmethyl-3,6-dioxo-piperazin-1-yl]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6384-18-5
L-Aspartic acid dimethyl ester

: 193287-77-3
[(2S,5S)-2-(Benzylcarbamoyl-methyl)-4-tert-butoxycarbonylmethyl-5-methoxycarbonylmethyl-3,6-dioxo-piperazin-1-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: i-BuOCOCl, NMM

2: HCl/EtOAc, amberlite IRA-400 (OH)

3: 120 h / 65 °C

4: Ag₂O / dimethylformamide

5: H₂ / Pd/C / methanol

6: EtOCOCl, NMM / tetrahydrofuran / -15 °C

With 4-methyl-morpholine; hydrogenchloride; Amberlite IRA-400; hydrogen; chloroformic acid ethyl ester; ethyl acetate; silver(l) oxide; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)00961-1

Reference yield:

: 193287-72-8
((2S,5S)-5-Methoxycarbonylmethyl-3,6-dioxo-piperazin-2-yl)-acetic acid benzyl ester

: 193287-77-3
[(2S,5S)-2-(Benzylcarbamoyl-methyl)-4-tert-butoxycarbonylmethyl-5-methoxycarbonylmethyl-3,6-dioxo-piperazin-1-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Ag₂O / dimethylformamide

2: H₂ / Pd/C / methanol

3: EtOCOCl, NMM / tetrahydrofuran / -15 °C

With 4-methyl-morpholine; hydrogen; chloroformic acid ethyl ester; silver(l) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)00961-1

Reference yield:

: 871927-90-1
α-L-aspartyl β-benzyl ester L-aspartic acid dimethyl ester

: 193287-77-3
[(2S,5S)-2-(Benzylcarbamoyl-methyl)-4-tert-butoxycarbonylmethyl-5-methoxycarbonylmethyl-3,6-dioxo-piperazin-1-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 120 h / 65 °C

2: Ag₂O / dimethylformamide

3: H₂ / Pd/C / methanol

4: EtOCOCl, NMM / tetrahydrofuran / -15 °C

With 4-methyl-morpholine; hydrogen; chloroformic acid ethyl ester; silver(l) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)00961-1