N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine

Base Information

Chemical Name:N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine
CAS No.:89637-85-4
Molecular Formula:C₂₆H₃₄N₁₀O₆
Molecular Weight:582.619
Hs Code.:

N-<sup>ε</sup>-<N-(4-amino-4-deoxy-N<sup>10</sup>-methylpteroyl)-L-γ-glutamyl>-L-lysine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine

Chemical Property:

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Technology Process of N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine

There total 4 articles about N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 89637-95-6
N-^α-(tert-butyloxycarbonyl)-N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine tert-butyl(α-Glu) ester

: 89637-85-4
N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine

Guidance literature:: With trifluoroacetic acid; for 0.166667h; Ambient temperature;
DOI:10.1021/jm00373a014

Reference yield:

: 79640-70-3
(S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid

: 89637-85-4
N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / diethyl phosphorocyanidate, Et₃N / dimethylformamide / 0 - 20 °C

2: 87 percent / Ba(OH)2*8H₂O / ethanol; H₂O / Ambient temperature

3: 57 percent / CF₃CO₂H / 0.17 h / Ambient temperature

With barium dihydroxide; diethyl cyanophosphonate; triethylamine; trifluoroacetic acid; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00373a014

Reference yield:

: 99532-86-2
N,2-[(1,1-dimethylethoxy)carbonyl]-L-lysine methyl ester hydrochloride

: 89637-85-4
N-^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysine

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / diethyl phosphorocyanidate, Et₃N / dimethylformamide / 0 - 20 °C

2: 87 percent / Ba(OH)2*8H₂O / ethanol; H₂O / Ambient temperature

3: 57 percent / CF₃CO₂H / 0.17 h / Ambient temperature

With barium dihydroxide; diethyl cyanophosphonate; triethylamine; trifluoroacetic acid; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00373a014