(5S,11R,13aR)-5-Benzyl-11-{5-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-pentyl}-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

Base Information

Chemical Name:(5S,11R,13aR)-5-Benzyl-11-{5-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-pentyl}-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone
CAS No.:88568-94-9
Molecular Formula:C₃₀H₄₃ClN₄O₆
Molecular Weight:591.148
Hs Code.:

(5S,11R,13aR)-5-Benzyl-11-{5-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-pentyl}-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

Synonyms:

Suppliers and Price of (5S,11R,13aR)-5-Benzyl-11-{5-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-pentyl}-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5S,11R,13aR)-5-Benzyl-11-{5-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-pentyl}-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5S,11R,13aR)-5-Benzyl-11-{5-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-pentyl}-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

There total 22 articles about (5S,11R,13aR)-5-Benzyl-11-{5-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-pentyl}-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 88568-93-8,88643-27-0
(R)-1-[(S)-2-(2-{(S)-2-Benzyloxycarbonylamino-7-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-heptanoylamino}-2-methyl-propionylamino)-3-phenyl-propionyl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester

: 88568-94-9,88643-28-1
(5S,11S,13aR)-5-Benzyl-11-{5-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-pentyl}-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

Guidance literature:: With hydrogen; palladium;
DOI:10.1016/S0040-4039(00)88171-X

Reference yield: 25.0%

: 88568-93-8,88643-27-0
(R)-1-[(S)-2-(2-{(R)-2-Benzyloxycarbonylamino-7-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-heptanoylamino}-2-methyl-propionylamino)-3-phenyl-propionyl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester

: 88568-94-9,88643-28-1
(5S,11R,13aR)-5-Benzyl-11-{5-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-pentyl}-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

Guidance literature:: With hydrogen; palladium;
DOI:10.1016/S0040-4039(00)88171-X

Reference yield:

: 50628-92-7
ethyl 6-oxo-7-octenoate

: 88568-94-9,88643-28-1
(5S,11S,13aR)-5-Benzyl-11-{5-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-pentyl}-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) HCl / 2.) Ethylenglykol

2: Red-Al

3: Pyridinium-chlorochromat

4: 84 percent / Lithium-diisopropylamid

5: H₂ / Pd

7: NaOH

8: DCCD

9: NaOH

10: DCCD

11: 85 percent / H₂ / Pd

With hydrogenchloride; sodium hydroxide; hydrogen; dicyclohexyl-carbodiimide; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; lithium diisopropyl amide; palladium;
DOI:10.1016/S0040-4039(00)88171-X