C₆₅H₇₇NO₁₅Si

Base Information

• Chemical Name: C₆₅H₇₇NO₁₅Si
• CAS No.: 618428-65-2
• Molecular Formula: C₆₅H₇₇NO₁₅Si
• Molecular Weight: 1140.41
• Mol file: 618428-65-2.mol

Synonyms:

Chemical Property of C₆₅H₇₇NO₁₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₅H₇₇NO₁₅Si

There total 8 articles about C₆₅H₇₇NO₁₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-phenylacrylic acid (140-10-3) + 2'-triisopropylsilyl-epi-paclitaxel (618428-05-0) → C65H77NO15Si (618428-65-2)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1016/S0968-0896(03)00181-0

Reference yield:

10-deacetylbaccatin III (32981-86-5,172018-16-5) → C65H77NO15Si (618428-65-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / imidazole / dimethylformamide

2: lithium hexamethyldisilazide / tetrahydrofuran / -40 - 0 °C

3: 80 percent / lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -40 °C

4: 78 percent / HCl / ethanol / 18 h / 20 °C

5: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; DMAP / CH₂Cl₂ / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(03)00181-0

Reference yield:

[4-(benzylideneamino)phenyl]methanol (783-08-4) → C65H77NO15Si (618428-65-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 96 percent / LDA / tetrahydrofuran

2: 88 percent / aq. cerium(IV) ammonium nitrate / acetonitrile / 2 h / -10 °C

3: 97 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

4: 80 percent / lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -40 °C

5: 78 percent / HCl / ethanol / 18 h / 20 °C

6: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; DMAP / CH₂Cl₂ / 20 °C

With hydrogenchloride; dmap; ammonium cerium(IV) nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

DOI:10.1016/S0968-0896(03)00181-0

upstream raw materials:

(E)-3-phenylacrylic acid

2'-triisopropylsilyl-epi-paclitaxel

10-deacetylbaccatin III

[4-(benzylideneamino)phenyl]methanol