(4-Chloro-butyl)-methyl-phosphoramidic acid benzyl ester (2R,3S,4R,5R)-5-(3-carbamoyl-[1,2,4]triazol-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:(4-Chloro-butyl)-methyl-phosphoramidic acid benzyl ester (2R,3S,4R,5R)-5-(3-carbamoyl-[1,2,4]triazol-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester
CAS No.:727398-83-6
Molecular Formula:C₂₀H₂₉ClN₅O₇P
Molecular Weight:517.906
Hs Code.:

(4-Chloro-butyl)-methyl-phosphoramidic acid benzyl ester (2R,3S,4R,5R)-5-(3-carbamoyl-[1,2,4]triazol-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

Synonyms:

Suppliers and Price of (4-Chloro-butyl)-methyl-phosphoramidic acid benzyl ester (2R,3S,4R,5R)-5-(3-carbamoyl-[1,2,4]triazol-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4-Chloro-butyl)-methyl-phosphoramidic acid benzyl ester (2R,3S,4R,5R)-5-(3-carbamoyl-[1,2,4]triazol-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4-Chloro-butyl)-methyl-phosphoramidic acid benzyl ester (2R,3S,4R,5R)-5-(3-carbamoyl-[1,2,4]triazol-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

There total 4 articles about (4-Chloro-butyl)-methyl-phosphoramidic acid benzyl ester (2R,3S,4R,5R)-5-(3-carbamoyl-[1,2,4]triazol-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 727398-83-6
(4-Chloro-butyl)-methyl-phosphoramidic acid benzyl ester (2R,3S,4R,5R)-5-(3-carbamoyl-[1,2,4]triazol-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP / tetrahydrofuran / 20 °C

2: 180 mg / aq. HCl / acetonitrile / 24 h / 20 °C / pH 2.0

With hydrogenchloride; dmap; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol049267j

Reference yield:

: 36791-04-5,66510-90-5
ribavirin

: 727398-83-6
(4-Chloro-butyl)-methyl-phosphoramidic acid benzyl ester (2R,3S,4R,5R)-5-(3-carbamoyl-[1,2,4]triazol-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / p-toluenesulfonic acid; pyridine / tetrahydrofuran / 20 °C

2: 810 mg / N-methylimidazole; pyridine / tetrahydrofuran / 24 h / 20 °C

3: DMAP / tetrahydrofuran / 20 °C

4: 180 mg / aq. HCl / acetonitrile / 24 h / 20 °C / pH 2.0

With pyridine; 1-methyl-1H-imidazole; hydrogenchloride; dmap; toluene-4-sulfonic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol049267j

Reference yield:

: 727398-97-2
1-(β-D-ribofuranosyl-2',3'-O-methoxymethylidene)-1,2,4-triazole-3-carboxamide

: 727398-83-6
(4-Chloro-butyl)-methyl-phosphoramidic acid benzyl ester (2R,3S,4R,5R)-5-(3-carbamoyl-[1,2,4]triazol-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 810 mg / N-methylimidazole; pyridine / tetrahydrofuran / 24 h / 20 °C

2: DMAP / tetrahydrofuran / 20 °C

3: 180 mg / aq. HCl / acetonitrile / 24 h / 20 °C / pH 2.0

With pyridine; 1-methyl-1H-imidazole; hydrogenchloride; dmap; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol049267j