2-tert-Butyl-3-{(E)-2-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-6-phenyl-pyridine

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Chemical Name:2-tert-Butyl-3-{(E)-2-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-6-phenyl-pyridine
CAS No.:123930-25-6
Molecular Formula:C₄₅H₅₀FNO₃Si
Molecular Weight:699.981
Hs Code.:

2-tert-Butyl-3-{(E)-2-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-6-phenyl-pyridine

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Chemical Property of 2-tert-Butyl-3-{(E)-2-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-6-phenyl-pyridine

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Technology Process of 2-tert-Butyl-3-{(E)-2-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-6-phenyl-pyridine

There total 14 articles about 2-tert-Butyl-3-{(E)-2-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-6-phenyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17094-34-7
ethyl pivaloylacetate

: 122253-69-4,123930-25-6
2-tert-Butyl-3-{(Z)-2-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-6-phenyl-pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: KOH, EtOH / diethyl ether / 3 h

2: ammonium acetate, FCl₃*6H₂O / acetic acid / 4 h / Heating

3: LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

4: PBr₃ / toluene; CH₂Cl₂ / 1 h / Ambient temperature

5: toluene / 5 h / Heating

6: 1.) 1.6 M n-BuLi / 1.) THF, hexane, 0.5 h, 2.) 1 h

With ammonium acetate; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; ethanol; phosphorus tribromide; In tetrahydrofuran; diethyl ether; dichloromethane; acetic acid; toluene;
DOI:10.1021/jm00163a010

Reference yield:

: 17094-34-7
ethyl pivaloylacetate

: 123930-25-6
2-tert-Butyl-3-{(E)-2-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-6-phenyl-pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: KOH, EtOH / diethyl ether / 3 h

2: ammonium acetate, FCl₃*6H₂O / acetic acid / 4 h / Heating

3: LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

4: PBr₃ / toluene; CH₂Cl₂ / 1 h / Ambient temperature

5: toluene / 5 h / Heating

6: 1.) 1.6 M n-BuLi / 1.) THF, hexane, 0.5 h, 2.) 1 h

With ammonium acetate; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; ethanol; phosphorus tribromide; In tetrahydrofuran; diethyl ether; dichloromethane; acetic acid; toluene;
DOI:10.1021/jm00163a010

Reference yield:

: 122253-02-5
2-(1,1-Dimethylethyl)-4-(4-fluorophenyl)-6-phenyl-3-pyridine methanol

: 122253-69-4,123930-25-6
2-tert-Butyl-3-{(Z)-2-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-6-phenyl-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: PBr₃ / toluene; CH₂Cl₂ / 1 h / Ambient temperature

2: toluene / 5 h / Heating

3: 1.) 1.6 M n-BuLi / 1.) THF, hexane, 0.5 h, 2.) 1 h

With n-butyllithium; phosphorus tribromide; In dichloromethane; toluene;
DOI:10.1021/jm00163a010